About: Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects
Creator	Bellastella, Antonio Bellastella, Giuseppe Bizzarro, • De Bellis, Annamaria Esposito, Katherine Giugliano, Dario Maiorino, Maria
Source	Medline; PMC
abstract	PURPOSE: This publication reviews the accepted knowledges and the findings still discussed on several features of autoimmune hypophysitis, including the most recently described forms, such as IgG4 and cancer immunotherapy- related hypophysitis. METHODS: The most characteristic findings and the pending controversies were derived from a literature review and previous personal experiences. A single paragraph focused on some atypical examples of the disease presenting under confounding pretences. RESULTS: Headache, visual field alterations and impaired pituitary secretion are the most frequent clinical findings of the disease. Pituitary biopsy, still considered the gold diagnostic standard, does not always receive consent from the patients. The role of magnetic resonance imaging is limited, as this disease may generate images similar to those of other diseases. The role of antipituitary and antihypothalamus antibodies is still discussed owing to methodological difficulties and also because the findings on the true pituitary antigen(s) are still debated. However, the low sensitivity and specificity of immunofluorescence, one of the more widely employed methods to detect these antibodies, may be improved, considering a predetermined cut-off titre and a particular kind of immunostaining. CONCLUSION: Autoimmune hypophysitis is a multifaceted disease, which may certainly be diagnosed by pituitary biopsy. However, the possible different clinical, laboratory and imaging features must be considered by the physician to avoid a misdiagnosis when examining a possibly affected patient. Therapeutic choice has to be made taking into account the clinical conditions and the degree of hypothalamic-pituitary involvement, but also considering that spontaneous remissions can occur.
has issue date	2016-08-08(xsd:dateTime)
bibo:doi	10.1007/s11102-016-0736-z
bibo:pmid	27503372
has license	no-cc
sha1sum (hex)	f9c8aa3f420dfd7c346234791ed46a15824cab49
schema:url	https://doi.org/10.1007/s11102-016-0736-z
resource representing a document's title	Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects
has PubMed Central identifier	PMC7088540
has PubMed identifier	27503372
schema:publication	Pituitary
resource representing a document's body	covid:f9c8aa3f420dfd7c346234791ed46a15824cab49#body_text
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