About: In vitro antiviral activity of fifteen plant extracts against avian infectious bronchitis virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	In vitro antiviral activity of fifteen plant extracts against avian infectious bronchitis virus
Creator	Drevinskas, Tomas Karpovaitė, Agneta Kubilienė, Loreta Lelešius, Raimundas Maruška, Audrius Mickienė, Rūta Ragažinskienė, Ona Tiso, Nicola
source	Medline; PMC
abstract	BACKGROUND: Avian infectious bronchitis (IB) is a disease that can result in huge economic losses in the poultry industry. The high level of mutations of the IB virus (IBV) leads to the emergence of new serotypes and genotypes, and limits the efficacy of routine prevention. Medicinal plants, or substances derived from them, are being tested as options in the prevention of infectious diseases such as IB in many countries. The objective of this study was to investigate extracts of 15 selected medicinal plants for anti-IBV activity. RESULTS: Extracts of S. montana, O. vulgare, M. piperita, M. officinalis, T. vulgaris, H. officinalis, S. officinalis and D. canadense showed anti-IBV activity prior to and during infection, while S. montana showed activity prior to and after infection. M. piperita, O. vulgare and T. vulgaris extracts had > 60 SI. In further studies no virus plaques (plaque reduction rate 100%) or cytopathogenic effect (decrease of TCID(50) from 2.0 to 5.0 log(10)) were detected after IBV treatment with extracts of M. piperita, D. canadense and T. vulgaris at concentrations of extracts ≥0.25 cytotoxic concentration (CC(50)) (P < 0.05). Both PFU number and TCID(50) increased after the use of M. piperita, D. canadense, T. vulgaris and M. officinalis extracts, the concentrations of which were 0.125 CC(50) and 0.25 CC(50) (P < 0.05). Real-time PCR detected IBV RNA after treatment with all plant extracts using concentrations of 1:2 CC(50), 1:4 CC(50) and 1:8 CC(50). Delta cycle threshold (Ct) values decreased significantly comparing Ct values of 1:2 CC(50) and 1:8 CC(50) dilutions (P < 0.05). CONCLUSIONS: Many extracts of plants acted against IBV prior to and during infection, but the most effective were those of M. piperita, T. vulgaris and D. canadense .
has issue date	2019-05-29(xsd:dateTime)
bibo:doi	10.1186/s12917-019-1925-6
bibo:pmid	31142304
has license	cc-by
sha1sum (hex)	f8c2f1a1903f8370c15b5be2e4d32e91f2641b03
schema:url	https://doi.org/10.1186/s12917-019-1925-6
resource representing a document's title	In vitro antiviral activity of fifteen plant extracts against avian infectious bronchitis virus
has PubMed Central identifier	PMC6540435
has PubMed identifier	31142304
schema:publication	BMC Vet Res
resource representing a document's body	covid:f8c2f1a1903f8370c15b5be2e4d32e91f2641b03#body_text
is schema:about of	named entity 'extracts' named entity 'infectious diseases' named entity 'derived' named entity 'Avian' named entity 'high level' named entity 'infection' named entity 'PFU' named entity 'ACTIVITY' named entity 'BUT' named entity '0.125' named entity '100%' named entity 'OBJECTIVE' named entity 'PLANT EXTRACTS' named entity 'EXTRACTS' named entity 'EFFECTIVE' named entity 'INFECTION' named entity 'SEROTYPES' named entity 'CONCENTRATION' named entity 'PLAQUES' named entity 'PRIOR TO' named entity 'ECONOMIC' named entity 'CONCENTRATIONS' named entity 'DELTA' named entity 'COUNTRIES' named entity 'ROUTINE' named entity '28P' named entity 'AVIAN INFECTIOUS BRONCHITIS' named entity 'DECREASED' named entity 'POULTRY INDUSTRY' named entity '3A8' named entity 'DERIVED' named entity 'VALUES' named entity 'RNA' named entity 'EMERGENCE' named entity 'TESTED' named entity 'LOG' named entity '0.05' named entity 'INFECTIOUS DISEASES' named entity 'MONTANA' named entity 'CONCLUSIONS' named entity 'HUGE' named entity 'DISEASE' named entity 'HIGH LEVEL' named entity 'CYTOPATHOGENIC EFFECT' named entity 'SELECTED' named entity 'LEADS' named entity 'PLANTS' named entity 'TREATMENT' named entity 'NEW' named entity 'AFTER TREATMENT' named entity 'GENOTYPES' named entity 'REAL-TIME PCR ' named entity 'MEDICINAL PLANTS' named entity 'STUDY' named entity 'COMPARING' named entity 'USING' named entity 'NUMBER' named entity 'PREVENTION' named entity 'DETECTED' named entity 'BEING' named entity 'REDUCTION RATE' named entity 'VIRUS' named entity '0.25' named entity 'RESULT' named entity 'TO INVESTIGATE' named entity 'INCREASED' named entity 'A50' named entity 'MUTATIONS' named entity 'SUBSTANCES' named entity 'IS A' named entity 'EFFICACY' named entity 'BACKGROUND' named entity 'PREVENTION OF' named entity '3A4'

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