About: Generation of protective pneumococcal-specific nasal resident memory CD4(+) T cells via parenteral immunization

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About: Generation of protective pneumococcal-specific nasal resident memory CD4(+) T cells via parenteral immunization Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Generation of protective pneumococcal-specific nasal resident memory CD4(+) T cells via parenteral immunization
Creator	Farber, Donna Cheung, Elaine Conaway, Evan Herd, Muriel Horwitz, Bruce Lucas, Katherine Malley, Richard Morton, Cynthia O'hara, Joanne Patik, Izabel Robertson, Nahid Sayed, Shorouk Singh Redhu, Naresh Thompson, Claudette
Source	PMC
abstract	The generation of tissue-resident memory T cells (T(RM)) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of T(RM) is one of the principal advantages of mucosally administered vaccines. We have previously shown that antigen-specific, IL-17-producing CD4(+) T cells can provide capsular antibody-independent protection against nasal carriage of Streptococcus pneumoniae; but whether pneumococcus-responsive T(RM) are localized within the nasal mucosa and are sufficient for protection from carriage has not been determined. Here we show that intranasal administration of live or killed pneumococci to mice generates pneumococcus-responsive IL-17A-producing CD4(+) mucosal T(RM). Furthermore, we show that these cells are sufficient to mediate long-lived, neutrophil-dependent protection against subsequent pneumococcal nasal challenge. Unexpectedly, and in contrast with the prevailing paradigm, we found that parenteral administration of killed pneumococci also generates protective IL-17A(+)CD4(+) T(RM) in the nasal mucosa. These results demonstrate a critical and sufficient role of T(RM) in prevention of pneumococcal colonization, and further that these cells can be generated by parenteral immunization. Our findings therefore have important implications regarding the generation of immune protection at mucosal surfaces by vaccination.
has issue date	2019-10-28(xsd:dateTime)
bibo:doi	10.1038/s41385-019-0218-5
bibo:pmid	31659300
has license	no-cc
sha1sum (hex)	f885efccd60a7d41bff1cc52eb152f201ada8044
schema:url	https://doi.org/10.1038/s41385-019-0218-5
resource representing a document's title	Generation of protective pneumococcal-specific nasal resident memory CD4(+) T cells via parenteral immunization
has PubMed Central identifier	PMC6917870
has PubMed identifier	31659300
schema:publication	Mucosal Immunol
resource representing a document's body	covid:f885efccd60a7d41bff1cc52eb152f201ada8044#body_text
is schema:about of	named entity 'immunity' named entity 'generation' named entity 'subject' named entity 'Public Access' named entity 'parenteral' named entity 'MEMORY T CELLS' named entity 'DOCUMENTS' named entity 'IL-17A' named entity 'ACADEMIC' named entity 'INTRANASAL ADMINISTRATION' named entity 'NASAL' named entity 'aspect' named entity 'mucosal' named entity 'capsular' named entity 'essential' named entity 'copy' named entity 'IL-17' named entity 'CD4 +' named entity 'Streptococcus pneumoniae' named entity 'vaccines' named entity 'mice' named entity 'CD4 +' named entity 'intranasal administration' named entity 'pneumococcus' named entity 'pneumococci' named entity 'parenteral' named entity 'nasopharynx' named entity 'parenteral' named entity 'goat' named entity 'numerical aperture' named entity 'IL-17A' named entity 'colon' named entity 'vaccination' named entity 'pathogen' named entity 'pneumococcus' named entity 'immunization' named entity 'immunization' named entity 'antigen' named entity 'Thermo Fisher Scientific' named entity 'intranasal' named entity 'CD4 +' named entity 'anesthesia' named entity 'aluminum hydroxide' named entity 'Boston Children's Hospital' named entity 'trimethoprim' named entity 'CLN' named entity 'pneumococcus' named entity 'C57BL/6J' named entity 'IL-17A' named entity 'CD4 +' named entity 'CD4 +' named entity 'Thy1' named entity 'pneumococcus' named entity '12 weeks' named entity 'lysed' named entity 'FBS' named entity 'lysis buffer' named entity 'antibody' named entity 'immunization' named entity 'CD4' named entity 'immunofluorescent' named entity 'pneumococcus' named entity 'parenteral' named entity 'FTY720' named entity 'intranasally' named entity 'spleen' named entity 'IgG' named entity 'pathogen'

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