About: Clinical findings in critical ill patients infected with SARS-Cov-2 in Guangdong Province, China: a multi-center, retrospective, observational study

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About: Clinical findings in critical ill patients infected with SARS-Cov-2 in Guangdong Province, China: a multi-center, retrospective, observational study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical findings in critical ill patients infected with SARS-Cov-2 in Guangdong Province, China: a multi-center, retrospective, observational study
Creator	Deng, Liehua Zhou, Liang Li, Yimin Liu, Xiaoqing Lin, Yun Liu, Dongdong Xu, Zhiheng Cai, Lihua Li, Jianwei Chen, Sibei Huang, Yongbo Lin, Zhimin Liu, Xuesong Xu, Yonghao He, Weiquan Huang, Linxi Zheng, Haichong Zhou, Lixin
Source	MedRxiv
abstract	Abstract Background In December 2019, human infection with a novel coronavirus, known as SARS-CoV-2, was identified in Wuhan, China. The mortality of critical illness was high in Wuhan. Information about critically ill patients with SARS-CoV-2 infection outside of Wuhan is scarce. We aimed to provide the clinical features, treatment, and prognosis of the critically ill patients with SARS-CoV-2 infection in Guangdong Province. Methods In this multi-centered, retrospective, observational study, we enrolled critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) in Guangdong Province. Demographic data, symptoms, laboratory findings, comorbidities, treatments, and prognosis were collected. Data were compared between patients with and without intubation. Results Forty-five critically ill patients with SARS-CoV-2 pneumonia were identified in 7 ICUs in Guangdong Province. The mean age was 56.7 years, and 29 patients (64.4%) were men. The most common symptoms at the onset of illness were high fever and cough. Majority of patients presented with lymphopenia and elevated lactate dehydrogenase. Treatment with antiviral drugs was initiated in all the patients. Thirty-seven patients (82.2%) had developed acute respiratory distress syndrome, and 13 (28.9%) septic shock. A total of 20 (44.4%) patients required intubation and 9 (20%) required extracorporeal membrane oxygenation. As of February 28th 2020, only one patient (2.2%) had died and half of them had discharged of ICU. Conclusions Infection with SARS-CoV-2 in critical illness is characterized by fever, lymphopenia, acute respiratory failure and multiple organ dysfunction. Compared with critically ill patients infected with SARS-CoV-2 in Wuhan, the mortality of critically ill patients in Guangdong Province was relatively low. These data provide some general understandings and experience for the critical patients with SARS-CoV-2 outside of Wuhan.
has issue date	2020-03-06(xsd:dateTime)
bibo:doi	10.1101/2020.03.03.20030668
has license	medrxiv
sha1sum (hex)	f879c69d61f14d7efc51023258d1361bc681d403
schema:url	https://doi.org/10.1101/2020.03.03.20030668
resource representing a document's title	Clinical findings in critical ill patients infected with SARS-Cov-2 in Guangdong Province, China: a multi-center, retrospective, observational study
resource representing a document's body	covid:f879c69d61f14d7efc51023258d1361bc681d403#body_text
is schema:about of	named entity 'Science' named entity 'Guangdong' named entity 'Emergency' named entity 'National Natural Science Foundation' named entity 'PROJECT' covid:arg/f879c69d61f14d7efc51023258d1361bc681d403 named entity 'WUHAN' named entity 'NATIONAL' named entity 'EMERGENCY' named entity 'CHINA' named entity 'SPECIAL' named entity 'DEPARTMENT' named entity '2019' named entity 'NATURAL SCIENCE' named entity 'FOUNDATION' named entity 'SCIENCE AND TECHNOLOGY' named entity 'HIGH' named entity 'CHINA' named entity 'CRITICAL ILLNESS' named entity 'SARS-COV-2' named entity 'BACKGROUND' named entity 'NOVEL CORONAVIRUS' named entity 'IDENTIFIED' named entity 'INFECTION' named entity 'KNOWN' named entity 'HUMAN' named entity 'MORTALITY' named entity 'DECEMBER' named entity 'critical illness' named entity 'Wuhan' named entity '2019' named entity 'China' named entity 'human infection' named entity 'Wuhan' named entity 'critical illness' named entity 'China' named entity 'Ministry of Science and Technology' named entity 'intubated' named entity 'preprint' named entity 'COVID-19' named entity 'antiviral' named entity 'COVID-19' named entity 'tachypnea' named entity 'lymphocyte' named entity 'CRRT' named entity 'critically ill patients' named entity 'clinical characteristics' named entity 'Chi-square test' named entity 'intubation' named entity 'SARS-CoV-2' named entity 'lymphopenia' named entity 'acute respiratory distress syndrome' named entity 'Wuhan' named entity 'antiviral drugs' named entity 'coronavirus' named entity 'antibacterial' named entity 'SARS' named entity 'ARDS' named entity 'intubation' named entity 'administrated' named entity 'preprint' named entity 'ARDS' named entity 'preprint' named entity 'intubated' named entity 'nasal cannula' named entity 'Chi-square test' named entity 'critically ill patients' named entity 'renal injury'

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