About: Steroid-Associated Hip Joint Collapse in Bipedal Emus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Steroid-Associated Hip Joint Collapse in Bipedal Emus
Creator	Qin, Ling Wang, Xin-Luan Xie, Xin-Hui Zhang, Ge Huang, Le Zheng, Li-Zhen He, Yi-Xin Liu, Ying Chen, Yang Lei, Ming Liu, Zhong Peng, Jiang Man, Chi-Wai Wang, Da-Ping Xiao, De-Ming Feng, Jian Fong, Tik-Pui, Daniel
Source	Medline; PMC
abstract	In this study we established a bipedal animal model of steroid-associated hip joint collapse in emus for testing potential treatment protocols to be developed for prevention of steroid-associated joint collapse in preclinical settings. Five adult male emus were treated with a steroid-associated osteonecrosis (SAON) induction protocol using combination of pulsed lipopolysaccharide (LPS) and methylprednisolone (MPS). Additional three emus were used as normal control. Post-induction, emu gait was observed, magnetic resonance imaging (MRI) was performed, and blood was collected for routine examination, including testing blood coagulation and lipid metabolism. Emus were sacrificed at week 24 post-induction, bilateral femora were collected for micro-computed tomography (micro-CT) and histological analysis. Asymmetric limping gait and abnormal MRI signals were found in steroid-treated emus. SAON was found in all emus with a joint collapse incidence of 70%. The percentage of neutrophils (Neut %) and parameters on lipid metabolism significantly increased after induction. Micro-CT revealed structure deterioration of subchondral trabecular bone. Histomorphometry showed larger fat cell fraction and size, thinning of subchondral plate and cartilage layer, smaller osteoblast perimeter percentage and less blood vessels distributed at collapsed region in SAON group as compared with the normal controls. Scanning electron microscope (SEM) showed poor mineral matrix and more osteo-lacunae outline in the collapsed region in SAON group. The combination of pulsed LPS and MPS developed in the current study was safe and effective to induce SAON and deterioration of subchondral bone in bipedal emus with subsequent femoral head collapse, a typical clinical feature observed in patients under pulsed steroid treatment. In conclusion, bipedal emus could be used as an effective preclinical experimental model to evaluate potential treatment protocols to be developed for prevention of ON-induced hip joint collapse in patients.
has issue date	2013-10-21(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0076797
bibo:pmid	24204675
has license	cc-by
sha1sum (hex)	f86ac2580002e6b374ec325717eeee73e84af1c5
schema:url	https://doi.org/10.1371/journal.pone.0076797
resource representing a document's title	Steroid-Associated Hip Joint Collapse in Bipedal Emus
has PubMed Central identifier	PMC3804596
has PubMed identifier	24204675
schema:publication	PLoS One
resource representing a document's body	covid:f86ac2580002e6b374ec325717eeee73e84af1c5#body_text
is schema:about of	named entity 'potential' named entity 'subchondral' named entity 'effective' named entity 'settings' named entity 'MRI' named entity 'patients' named entity 'cartilage' named entity 'The combination' named entity 'blood vessels' named entity 'induction' named entity 'fat cell' named entity 'induce' named entity 'Emus' named entity 'STEROID' named entity 'CURRENT' named entity 'POOR' named entity 'STRUCTURE' named entity 'NEUTROPHILS' named entity 'BLOOD COAGULATION' named entity 'PERFORMED' named entity 'COMPARED' named entity 'BLOOD VESSELS' named entity 'STUDY' named entity 'MICRO-COMPUTED TOMOGRAPHY' named entity 'ASSOCIATED' named entity 'PERCENTAGE' named entity 'TREATMENT PROTOCOLS' named entity 'GROUP' named entity 'LIMPING' named entity 'FEMORAL HEAD' named entity 'ADDITIONAL' named entity 'SIGNALS' named entity 'CONCLUSION' named entity 'LIPOPOLYSACCHARIDE' named entity 'MODEL OF' named entity 'OBSERVED' named entity 'TYPICAL' named entity 'INCIDENCE' named entity 'EMU' named entity 'ABNORMAL MRI' named entity 'HIP JOINT' named entity 'INDUCTION' named entity 'INCREASED' named entity 'WEEK' named entity 'ROUTINE EXAMINATION' named entity 'SAFE' named entity 'EVALUATE' named entity 'GAIT' named entity 'COLLAPSED' named entity 'CARTILAGE' named entity 'FAT CELL' named entity 'TRABECULAR BONE' named entity 'THINNING' named entity 'COLLECTED' named entity 'COLLAPSE' named entity 'PROTOCOL' named entity 'EFFECTIVE' named entity 'BLOOD' named entity 'METHYLPREDNISOLONE' named entity 'SUBCHONDRAL BONE' named entity 'LPS' named entity 'TESTING' named entity 'ADULT MALE' named entity 'PATIENTS'

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