About: Local Antigen Encounter Is Essential for Establishing Persistent CD8(+) T-Cell Memory in the CNS

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About: Local Antigen Encounter Is Essential for Establishing Persistent CD8(+) T-Cell Memory in the CNS Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Local Antigen Encounter Is Essential for Establishing Persistent CD8(+) T-Cell Memory in the CNS
Creator	Gasteiger, Georg Fonnes, Masja Nazerai, Loulieta Christensen, Jan Nolz, Jeffrey Pavelko, Kevin Schøller, Amalie Thomsen, Allan
source	Medline; PMC
abstract	While the brain is considered an immune-privileged site, the CNS may nevertheless be the focus of immune mediated inflammation in the case of infection and certain autoimmune diseases, e.g., multiple sclerosis. As in other tissues, it has been found that acute T-cell infiltration may be followed by establishment of persistent local T-cell memory. To improve our understanding regarding the regulation of putative tissue resident memory T (Trm) cells in CNS, we devised a new model system for studying the generation of Trm cells in this site. To this purpose, we exploited the fact that the CNS may be a sanctuary for adenoviral infection, and to minimize virus-induced disease, we chose replication-deficient adenoviruses for infection of the CNS. Non-replicating adenoviruses are known to be highly immunogenic, and our studies demonstrate that intracerebral inoculation causes marked local T-cell recruitment, which is followed by persistent infiltration of the CNS parenchyma by antigen specific CD8(+) T cells. Phenotypical analysis of CNS infiltrating antigen specific CD8(+) T cells was consistent with these cells being Trms. Regarding the long-term stability of the infiltrate, resident CD8(+) T cells expressed high levels of the anti-apoptotic molecule Bcl-2 as well as the proliferation marker Ki-67 suggesting that the population is maintained through steady homeostatic proliferation. Functionally, memory CD8(+) T cells from CNS matched peripheral memory cells with regard to capacity for ex vivo cytotoxicity and cytokine production. Most importantly, our experiments revealed a key role for local antigen encounter in the establishment of sustained CD8(+) T-cell memory in the brain. Inflammation in the absence of cognate antigen only led to limited and transient infiltration by antigen specific CD8(+) T cells. Together these results indicate that memory CD8(+) T cells residing in the CNS predominantly mirror previous local infections and immune responses to local autoantigens.
has issue date	2019-03-04(xsd:dateTime)
bibo:doi	10.3389/fimmu.2019.00351
bibo:pmid	30886617
has license	cc-by
sha1sum (hex)	f7ff81d2d3ae773aa28836cc485617983d7499ef
schema:url	https://doi.org/10.3389/fimmu.2019.00351
resource representing a document's title	Local Antigen Encounter Is Essential for Establishing Persistent CD8(+) T-Cell Memory in the CNS
has PubMed Central identifier	PMC6409353
has PubMed identifier	30886617
schema:publication	Front Immunol
resource representing a document's body	covid:f7ff81d2d3ae773aa28836cc485617983d7499ef#body_text
is schema:about of	named entity 'FOLLOWED BY' named entity 'CERTAIN' named entity 'STABILITY' named entity 'HOMEOSTATIC' named entity 'CELL INFILTRATION ' named entity 'FOUND' named entity 'KEY' named entity 'SUSTAINED' named entity 'T CELLS' named entity 'INFILTRATING' named entity 'REPLICATION' named entity 'KNOWN' named entity 'LOCAL' named entity 'LED' named entity 'DEFICIENT' named entity 'CNS PARENCHYMA' named entity 'PERSISTENT' named entity 'REGULATION' named entity 'ENCOUNTER' named entity 'PROLIFERATION MARKER' named entity 'STUDIES' named entity 'FACT' named entity 'ABSENCE OF' named entity 'MATCHED' named entity 'PREVIOUS' named entity 'MARKED' named entity 'MAY BE A' named entity 'UNDERSTANDING' named entity 'AUTOIMMUNE DISEASES' named entity 'PROLIFERATION' named entity 'ROLE' named entity 'MAY BE' named entity 'MEMORY' named entity 'ESTABLISHMENT' named entity 'MOLECULE' named entity 'LIMITED' named entity 'HIGHLY' named entity 'INOCULATION' named entity 'ANALYSIS' named entity 'VIRUS' named entity 'IMMUNE RESPONSES' named entity 'INFILTRATE' named entity 'MULTIPLE SCLEROSIS' named entity 'PERIPHERAL' named entity 'NEW' named entity 'INFILTRATION' named entity 'ENCOUNTER' named entity 'THE BRAIN' named entity 'CHOSE' named entity 'CYTOTOXICITY' named entity 'CASE' named entity 'TISSUES' named entity 'PERSISTENT' named entity 'CD8' named entity 'CELL MEMORY' named entity 'ADENOVIRUSES' named entity 'INDUCED' named entity 'EXPERIMENTS' named entity 'NON-' named entity 'REPLICATING' named entity 'EX VIVO' named entity 'RESULTS' named entity 'T-CELL' named entity 'CELLS' named entity 'SANCTUARY' named entity 'ESSENTIAL' named entity 'INFECTION' named entity 'RESIDENT' named entity 'PRIVILEGED' named entity 'LOCAL' named entity 'CNS' named entity 'ANTIGEN' named entity 'CD8' named entity 'RECRUITMENT'

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