About: Mannose-Binding Lectin (MBL) gene polymorphisms in susceptibility to pulmonary tuberculosis among the Lur population of Lorestan Province of Iran

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About: Mannose-Binding Lectin (MBL) gene polymorphisms in susceptibility to pulmonary tuberculosis among the Lur population of Lorestan Province of Iran Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Mannose-Binding Lectin (MBL) gene polymorphisms in susceptibility to pulmonary tuberculosis among the Lur population of Lorestan Province of Iran
Creator	Amiri, Ali Anbari, Khatereh Pouremadi, Flora Sabooteh, Toomaj Shahsavar, Farhad
source	PMC
abstract	OBJECTIVE: Tuberculosis (TB) is caused by infection of Mycobacterium tuberculosis. Host genetic variability is an important determinant of the risk of developing TB in humans. Although the association between MBL polymorphisms and TB has been studied in various populations, the results are controversial. The aim of this study was to investigate mannose-binding lectin (MBL) gene polymorphisms with susceptibility to pulmonary tuberculosis (PTB) in a Lur population of Iran. METHODS: In this case-control study, four functional MBL gene polymorphisms (HL, XY, PQ and AB) were genotyped by using PCR Single Strand Conformation Polymorphism (SSCP) technique in a Lur population living in Lorestan Province, consisting of 100 patients with pulmonary tuberculosis (PTB) age and sex matched 100 healthy controls (HCs). Association analyses were performed with the SPSS 21 statistical software. RESULTS: We found that MBL (HH) genotype polymorphism significantly was associated with increased susceptibility to TB (35% in patients vs. 22% in controls, P = 0.0417, OR = 1.909, %95 CI = 1.020–3.573). Additionally, H allele showed a significant association with increased risk of TB (56.5% in patients vs. 46% in controls, P = 0.0357, OR = 1.525, %95 CI = 1.028–2.262). Also, the distribution of L allele in patients was significantly lower frequency in TB patients compared to controls (43.5% vs. 54%, P = 0.0357, OR = 0.656, %95 CI = 0.442–0.973). However, the allelic and genotypic frequencies of AB, XY and PQ polymorphisms were not significantly different between the patients and the controls. We couldn't detect any significant differences between haplotypes among TB patients and healthy controls. CONCLUSIONS: Our findings demonstrated that HH genotype and H allele may increase the susceptibility to pulmonary TB in the Lur population of Iran, although L allele may decrease the susceptibility to pulmonary TB in this population. We suggest that it is necessary to further more studies with larger sample size and other ethnic population.
has issue date	2017-05-04(xsd:dateTime)
bibo:doi	10.1016/j.gdata.2017.05.005
bibo:pmid	28540182
has license	cc-by
sha1sum (hex)	f79e36092b45aef0e928b577166a4c44198f2825
schema:url	https://doi.org/10.1016/j.gdata.2017.05.005
resource representing a document's title	Mannose-Binding Lectin (MBL) gene polymorphisms in susceptibility to pulmonary tuberculosis among the Lur population of Lorestan Province of Iran
has PubMed Central identifier	PMC5432655
has PubMed identifier	28540182
schema:publication	Genom Data
resource representing a document's body	covid:f79e36092b45aef0e928b577166a4c44198f2825#body_text
is schema:about of	named entity 'SUSCEPTIBILITY' named entity 'detect' named entity 'allelic' named entity 'matched' named entity 'patients' named entity 'Methods' named entity 'controls' named entity 'living' named entity 'polymorphisms' named entity 'Lur' named entity 'MANNOSE-BINDING LECTIN' named entity 'LIVING' named entity 'DEMONSTRATED' named entity 'ASSOCIATION' named entity 'PULMONARY TUBERCULOSIS' named entity 'POPULATION' named entity 'HUMANS' named entity 'TUBERCULOSIS' named entity 'PCR' named entity '262' named entity 'ETHNIC' named entity 'HOST' named entity 'CONCLUSIONS' named entity 'INCREASED RISK' named entity '573' named entity 'DETERMINANT' named entity 'SINGLE STRAND CONFORMATION POLYMORPHISM' named entity 'GENE POLYMORPHISMS' named entity '100' named entity 'AGE' named entity 'INCREASED SUSCEPTIBILITY' named entity '656' named entity 'AIM' named entity 'INCREASE' named entity 'MBL' named entity '020' named entity 'HEALTHY' named entity 'IMPORTANT' named entity 'IRAN' named entity 'STATISTICAL SOFTWARE' named entity '0.0417' named entity 'RESULTS' named entity 'FREQUENCY' named entity 'FUNCTIONAL' named entity 'DECREASE' named entity 'PATIENTS' named entity 'METHODS' named entity 'PULMONARY TUBERCULOSIS' named entity 'SEX' named entity '442' named entity 'FINDINGS' named entity 'STUDIES' named entity 'GENETIC VARIABILITY' named entity 'PERFORMED' named entity '2595' named entity 'SPSS' named entity 'STUDY' named entity 'USING' named entity 'HAPLOTYPES' named entity 'DETECT' named entity 'OUR' named entity 'ALLELE' named entity '028' named entity 'GENOTYPIC' named entity 'MANNOSE-BINDING LECTIN' named entity 'POPULATIONS' named entity 'PULMONARY TB' named entity 'IRAN' named entity '525' named entity 'RISK OF' named entity 'MYCOBACTERIUM TUBERCULOSIS' named entity 'CASE-CONTROL STUDY' named entity 'VARIOUS' named entity 'FOUND' named entity 'SIGNIFICANT' named entity 'LOWER' named entity 'SUGGEST'

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