About: Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions
Creator	Lehto, Taavi El Andaloussi, Samir Langel, Ülo Ezzat, Kariem Smith, C El-Sayed, Ramy Magdy, Tarek Zaghloul, Eman
Source	Elsevier; Medline; PMC
abstract	Abstract Cell-penetrating peptides (CPPs) are short cationic peptides that have been extensively studied as drug delivery vehicles for proteins, nucleic acids and nanoparticles. However, the formulation of CPP-based therapeutics into different pharmaceutical formulations and their stability in relevant biological environments have not been given the same attention. Here, we show that a newly developed CPP, PepFect 14 (PF14), forms non-covalent nanocomplexes with short interfering RNA (siRNA), which are able to elicit efficient RNA-interference (RNAi) response in different cell-lines. RNAi effect is obtained at low siRNA doses with a unique kinetic profile. Furthermore, the solid dispersion technique is utilized to formulate PF14/siRNA nanocomplexes into solid formulations that are as active as the freshly prepared nanocomplexes in solution. Importantly, the nanocomplexes are stable and active in mediating RNAi response after incubation with simulated gastric fluid (SGF) that is highly acidic. These results demonstrate the activity of PF14 in delivering and protecting siRNA in different pharmaceutical forms and biological environments.
has issue date	2012-08-20(xsd:dateTime)
bibo:doi	10.1016/j.jconrel.2012.06.006
bibo:pmid	22698942
has license	els-covid
sha1sum (hex)	f78d774f07f94c64a69d7bbb43f9008a59897d2b
schema:url	https://doi.org/10.1016/j.jconrel.2012.06.006
resource representing a document's title	Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions
has PubMed Central identifier	PMC7126485
has PubMed identifier	22698942
schema:publication	Journal of Controlled Release
resource representing a document's body	covid:f78d774f07f94c64a69d7bbb43f9008a59897d2b#body_text
is schema:about of	named entity 'solution' named entity 'RNAi' named entity 'mediating' named entity 'extensively' named entity 'RNAi' named entity 'CONDITIONS' named entity 'SIRNA' named entity 'NANOPARTICLES' named entity 'GASTRIC FLUID' named entity 'NEWLY' named entity 'SOLID' named entity 'VEHICLES' named entity 'INCUBATION' named entity 'SIMULATED' named entity 'SHORT INTERFERING RNA' named entity 'ENVIRONMENTS' named entity 'FORMS' named entity 'LINES' named entity 'HAVE' named entity 'FORMULATION' named entity 'MEDIATING' named entity 'COVALENT' named entity 'ELICIT' named entity 'RNA-INTERFERENCE' named entity 'THEIR' named entity 'SIRNA' covid:arg/f78d774f07f94c64a69d7bbb43f9008a59897d2b named entity 'GASTRIC' named entity 'SOLID' named entity 'SOLUTION' named entity 'CELL' named entity 'CELL-PENETRATING PEPTIDE' named entity 'FORMULATION' named entity 'NON-' named entity 'DISPERSION' named entity 'BASED' named entity 'PROTEINS' named entity 'PREPARED' named entity 'UNIQUE' named entity 'HERE' named entity 'STABILITY' named entity 'OBTAINED' named entity 'KINETIC' named entity 'THESE' named entity 'TECHNIQUE' named entity 'RNAI' named entity 'ACTIVE' named entity 'DRUG DELIVERY' named entity 'HIGHLY' named entity 'LOW' named entity 'STABILITY' named entity 'NUCLEIC ACIDS' named entity 'PEPTIDES' named entity 'PROTECTING' named entity 'PHARMACEUTICAL' named entity 'EFFICIENT' named entity 'DIFFERENT' named entity 'ACIDIC' named entity 'SHORT' named entity 'THERAPEUTICS' named entity 'ATTENTION' named entity 'CPP' named entity 'EFFECT' named entity 'RESULTS' named entity 'THEIR' named entity 'STABLE' named entity 'ACTIVITY' named entity 'RESPONSE' named entity 'RELEVANT' named entity 'SIMULATED' named entity 'GIVEN' named entity 'DOSES' named entity 'PROFILE' named entity 'CELL-PENETRATING PEPTIDES'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software