About: Monoclonal antibodies versus reverse transcription‐PCR for detection of respiratory viruses in a patient population with respiratory tract infections admitted to hospital

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Monoclonal antibodies versus reverse transcription‐PCR for detection of respiratory viruses in a patient population with respiratory tract infections admitted to hospital
Creator	Baldanti, Fausto Campanini, Giulia Rovida, Francesca Gerna, Giuseppe Paolucci, Stefania Percivalle, Elena Sarasini, Antonella Torsellini, Maria Revello, M Zavattoni, Maurizio
Source	Medline; PMC
abstract	In the winter season 2001–2002, 239 nasopharyngeal aspirate and 15 bronchoalveolar lavage samples from 208 patients (135 pediatric and 73 adults, including 19 lung transplant recipients) admitted to hospital because of an acute respiratory tract infection were examined for rapid diagnosis of respiratory viruses by two diagnostic approaches: immunological, using specific monoclonal antibodies (MAb); and molecular, using specific reverse transcription (RT)‐PCR assays. Both methods detected influenza viruses A (H1N1 and H3N2) and B, human parainfluenza virus types 1 to 3, human respiratory syncytial virus (hRSV) types A and B, and human adenoviruses. In addition, human coronavirus (hCoV) groups I (229E‐like) and II (OC43‐like), as well as the new human metapneumovirus (hMPV), types A and B, were searched for by RT‐PCR alone. When results obtained by both methods were added, the overall percentage of patients positive for at least one respiratory virus peaked at 44.2%, involving 92/208 patients (81 pediatric, and 11 adults), while 116 patients (55.8%) were negative for any respiratory virus tested. The most common circulating virus was hRSV, infecting 54 (25.9%) patients (24 type A, and 30 type B strains), followed by hMPV, infecting 12 (5.8%) patients (7 type A and 5 type B strains). Coinfections by two respiratory viruses interested 11 (5.3%) patients, and 9 (81.8%) of these were infected by hRSV in association with another respiratory virus. In the great majority of infected children, hRSV and hMPV were associated with lower respiratory tract infections. In lung transplant recipients, viruses present in bronchoalveolar lavage appeared to be associated frequently with lower respiratory tract infections. In conclusion: the combination of immunological and molecular assays is the most sensitive approach to the diagnosis of respiratory viral infections; and infections caused by the less investigated hCoVs and hMPVs represent a fair proportion of respiratory infections. J. Med. Virol. 75:336–347, 2005. © 2004 Wiley‐Liss, Inc.
has issue date	2004-12-15(xsd:dateTime)
bibo:doi	10.1002/jmv.20276
bibo:pmid	15602736
has license	no-cc
sha1sum (hex)	f781f3a706239341348c791f54260e16ed0a7bd5
schema:url	https://doi.org/10.1002/jmv.20276
resource representing a document's title	Monoclonal antibodies versus reverse transcription‐PCR for detection of respiratory viruses in a patient population with respiratory tract infections admitted to hospital
has PubMed Central identifier	PMC7166428
has PubMed identifier	15602736
schema:publication	J Med Virol
resource representing a document's body	covid:f781f3a706239341348c791f54260e16ed0a7bd5#body_text
is schema:about of	named entity 'OC43' named entity 'respiratory' named entity 'aspirate' named entity 'strains' named entity 'patients' named entity 'lung transplant' named entity 'MAb' named entity 'Antibodies' named entity 'Monoclonal' named entity 'LUNG TRANSPLANT' named entity 'INFECTIONS' named entity 'respiratory tract' named entity 'infecting' named entity 'lung transplant' named entity 'assays' named entity 'adults' named entity 'viruses' named entity '2001' named entity 'specific' named entity 'patients' named entity 'sensitive' named entity 'winter' named entity 'tested' named entity 'infections' named entity 'respiratory tract infections' named entity 'human respiratory syncytial virus' named entity 'immunological' named entity 'great' named entity 'adenoviruses' named entity 'viruses' named entity 'virus' named entity 'respiratory' named entity 'Patient' named entity 'PCR' named entity 'Coinfections' named entity 'H1N1' named entity 'hMPV' named entity 'lung transplant' named entity 'hRSV' named entity 'bronchoalveolar lavage' named entity 'lower respiratory tract infections' named entity 'influenza viruses' named entity 'bronchoalveolar lavage' named entity 'H3N2' named entity 'nasopharyngeal aspirate' named entity 'hRSV' named entity 'reverse transcription' named entity 'bronchopneumonia' named entity 'viruses' named entity 'plasmid' named entity 'Kehl' named entity 'molecular methods' named entity 'virus' named entity 'epithelial' named entity 'MAbs' named entity 'lower respiratory infections' named entity 'polymerase chain reaction' named entity 'viruses' named entity 'infection' named entity 'MAbs' named entity 'human lung' named entity 'trypsinized' named entity 'viruses' named entity 'respiratory tract' named entity 'molecular methods' named entity 'primary infection' named entity 'molecular methods' named entity 'influenza viruses' named entity 'virus isolation' named entity 'direct fluorescent antibody' named entity 'virus' named entity 'respiratory tract'

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