About: Implications of Host Genetic Variation on the Risk and Prevalence of Infectious Diseases Transmitted Through the Environment

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About: Implications of Host Genetic Variation on the Risk and Prevalence of Infectious Diseases Transmitted Through the Environment Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Implications of Host Genetic Variation on the Risk and Prevalence of Infectious Diseases Transmitted Through the Environment
Creator	Doeschl-Wilson, Andrea Conington, J Davidson, R Hutchings, M Roughsedge, T Villanueva, B
Source	Medline; PMC
abstract	Previous studies have shown that host genetic heterogeneity in the response to infectious challenge can affect the emergence risk and the severity of diseases transmitted through direct contact between individuals. However, there is substantial uncertainty about the degree and direction of influence owing to different definitions of genetic variation, most of which are not in line with the current understanding of the genetic architecture of disease traits. Also, the relevance of previous results for diseases transmitted through environmental sources is unclear. In this article a compartmental genetic–epidemiological model was developed to quantify the impact of host genetic diversity on epidemiological characteristics of diseases transmitted through a contaminated environment. The model was parameterized for footrot in sheep. Genetic variation was defined through continuous distributions with varying shape and degree of dispersion for different disease traits. The model predicts a strong impact of genetic heterogeneity on the disease risk and its progression and severity, as well as on observable host phenotypes, when dispersion in key epidemiological parameters is high. The impact of host variation depends on the disease trait for which variation occurs and on environmental conditions affecting pathogen survival. In particular, compared to homogeneous populations with the same average susceptibility, disease risk and severity are substantially higher in populations containing a large proportion of highly susceptible individuals, and the differences are strongest when environmental contamination is low. The implications of our results for the recording and analysis of disease data and for predicting response to selection are discussed.
has issue date	2011-07-01(xsd:dateTime)
bibo:doi	10.1534/genetics.110.125625
bibo:pmid	21527777
has license	no-cc
sha1sum (hex)	f74d6f598edd77d5ececd51da9d900910b21186d
schema:url	https://doi.org/10.1534/genetics.110.125625
resource representing a document's title	Implications of Host Genetic Variation on the Risk and Prevalence of Infectious Diseases Transmitted Through the Environment
has PubMed Central identifier	PMC3176547
has PubMed identifier	21527777
schema:publication	Genetics
resource representing a document's body	covid:f74d6f598edd77d5ececd51da9d900910b21186d#body_text
is schema:about of	named entity 'RISK' named entity 'The' named entity 'Genetic variation' named entity 'sheep' named entity 'parameterized' named entity 'response' named entity 'individuals' named entity 'Infectious Diseases' named entity 'Risk' named entity 'PREVALENCE' named entity 'INFECTIOUS DISEASES' named entity 'COMPARED' named entity 'KEY' named entity 'PATHOGEN' named entity 'ANALYSIS' named entity 'CURRENT' named entity 'DISTRIBUTIONS' named entity 'PREVIOUS' named entity 'ENVIRONMENT' named entity 'SHAPE' named entity 'UNCLEAR' named entity 'SEVERITY' named entity 'CONTAMINATED' named entity 'DIRECTION' named entity 'RECORDING' named entity 'PARAMETERS' named entity 'DEFINED' named entity 'OBSERVABLE' named entity 'GENETIC VARIATION' named entity 'POPULATIONS' named entity 'QUANTIFY' named entity 'MODEL' named entity 'UNDERSTANDING' named entity 'RESULTS' named entity 'SUSCEPTIBLE' named entity 'CONTINUOUS' named entity 'GENETIC' named entity 'RESPONSE TO' named entity 'STRONG' named entity 'HAVE' named entity 'AFFECT' named entity 'INFECTIOUS' named entity 'INDIVIDUALS' named entity 'VARIATION' named entity 'GENETIC HETEROGENEITY' named entity 'AFFECTING' named entity 'PREDICTING' named entity 'CONDITIONS' named entity 'LOW' named entity 'SELECTION' named entity 'EPIDEMIOLOGICAL MODEL' named entity 'SUSCEPTIBILITY' named entity 'GENETIC DIVERSITY' named entity 'HIGH' named entity 'DIFFERENT' named entity 'ITS' named entity 'LARGE' named entity 'HOST' named entity 'TRAIT' named entity 'PARAMETERIZED' named entity 'OUR' named entity 'SHEEP' named entity 'CHALLENGE' named entity 'ARTICLE' named entity 'DISEASE RISK' named entity 'SOURCES' named entity 'PHENOTYPES' named entity 'TRANSMITTED' named entity 'GENETIC VARIATION' named entity 'STUDIES' named entity 'DISEASE' named entity 'PROPORTION' named entity 'UNCERTAINTY' named entity 'INFLUENCE' named entity 'HOMOGENEOUS' named entity 'DISEASE DATA'

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