About: Persistent viral RNA shedding after COVID‐19 symptom resolution in older convalescent plasma donors

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Persistent viral RNA shedding after COVID‐19 symptom resolution in older convalescent plasma donors
Creator	Connor, Joseph Correspondence, William Hartman, Hartman, William Hess, Aaron
source	Medline; PMC
abstract	INTRODUCTION: The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is responsible for a worldwide pandemic. While the medical community understands the mode of viral transmission, less is known about how long viral shedding occurs once viral symptoms have resolved. Our objective was to determine how long the SARS‐CoV‐2 remains detectable following self‐reporting of viral symptom resolution. METHODS: This study was approved by the University of Wisconsin Institutional Review Board. A cohort of patients who were previously SARS‐CoV‐2 positive less than 28 days after self‐reported symptom resolution were retested for proof of viral recovery by nasal swab reverse transcriptase polymerase chain reaction for SARS‐CoV‐2 RNA. RESULTS: A total of 152 potential participants were screened, of which 5 declined, 54 were ineligible, and 93 were recruited; 86 of 93 completed testing. Eleven of 86 (13%) were still positive at a median of 19 days (range, 12‐24 days) after symptom resolution. Positive participants were significantly older than negative participants (mean, 54 years; 95% confidence interval [CI], 44‐63 vs 42 years; 95% CI, 38‐46; P = .024). C (T) values were significantly, inversely associated with age (β = −.04; r (2) = 0.389; P = .04). The number of days since symptom recovery was not apparently different between positive and negative participants. CONCLUSION: We found evidence of persistent viral shedding in nasopharyngeal secretions more than 2 weeks after resolution of symptoms from confirmed COVID‐19 infection. Persistent shedding was more common in older participants, and viral load was higher among older positive participants. These results underscore the necessity of testing COVID‐19 convalescent plasma donors less than 28 days after symptom resolution.
has issue date	2020-06-24(xsd:dateTime)
bibo:doi	10.1111/trf.15927
bibo:pmid	32533556
has license	no-cc
sha1sum (hex)	f71938cbae4b27f7b81e9ce06a2818c3f183b9f1
schema:url	https://doi.org/10.1111/trf.15927
resource representing a document's title	Persistent viral RNA shedding after COVID‐19 symptom resolution in older convalescent plasma donors
has PubMed Central identifier	PMC7323103
has PubMed identifier	32533556
schema:publication	Transfusion
resource representing a document's body	covid:f71938cbae4b27f7b81e9ce06a2818c3f183b9f1#body_text
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