About: Isolation and characterization of an astrovirus causing fatal visceral gout in domestic goslings

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About: Isolation and characterization of an astrovirus causing fatal visceral gout in domestic goslings Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Isolation and characterization of an astrovirus causing fatal visceral gout in domestic goslings
Creator	Meng, Li Wang, Jun Zhang, Lijiao Cao, Yanxin Cui, Guolin Fu, Guanghua Hu, Xueying Huang, Yu Su, Jingliang Sun, Mengxu Zhang, Qingshui
Source	Medline; PMC
abstract	Astroviruses are recognized as a leading cause of gastroenteritis in humans and animals. They are also associated with extra-intestinal diseases, such as hepatitis in ducklings, nephritis in chickens, and encephalitis in cattle. In February 2017, a fatal infection of goslings characterized by visceral urate deposition was reported in the Shandong province, China. Our systematic investigation led to the isolation of an astrovirus, designated AAstV/Goose/CHN/2017/SD01, and similar disease was reproduced by experimental infection of healthy goslings, fulfilling Koch’s postulates. The isolated astrovirus replicated well and resulted in 100% mortality of goose embryos. Complete genome sequence analysis revealed that the isolate was genetically distinct from known astroviruses and closely related to members of the avastrovirus genogroup II. Experimental infection showed that the isolate was highly pathogenic in goslings, causing clinical signs, growth repression and in many cases mortality. Histopathological examination indicated that lesions occurred mainly in the kidneys of infected birds. However, virus-specific genomic RNA was detected in all representative tissues, and virus shedding was detected up to 12 days after inoculation, suggesting that the isolate was able to spread systemically and replicate efficiently in vivo. Collectively, our study demonstrates, for the first time, the etiological role of a genetically distinct astrovirus in the fatal infection of goslings.
has issue date	2018-04-19(xsd:dateTime)
bibo:doi	10.1038/s41426-018-0074-5
bibo:pmid	29674726
has license	cc-by
sha1sum (hex)	f715f94955504e6dbe3963ec0ccebb0a431e7c4e
schema:url	https://doi.org/10.1038/s41426-018-0074-5
resource representing a document's title	Isolation and characterization of an astrovirus causing fatal visceral gout in domestic goslings
has PubMed Central identifier	PMC5908792
has PubMed identifier	29674726
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:f715f94955504e6dbe3963ec0ccebb0a431e7c4e#body_text
is schema:about of	named entity 'pathogenic' named entity 'fatal' named entity 'genetically' named entity 'gastroenteritis' named entity 'astrovirus' named entity 'VISCERAL GOUT' named entity 'VIRUS SHEDDING' named entity 'LED' named entity '100%' named entity 'KIDNEYS' named entity 'HISTOPATHOLOGICAL' named entity 'SIMILAR' named entity 'NEPHRITIS' named entity 'INOCULATION' named entity 'FATAL' named entity 'HIGHLY' named entity 'EXTRA' named entity 'GASTROENTERITIS' named entity 'SPECIFIC' named entity 'FEBRUARY' named entity 'LESIONS' named entity '27S' named entity 'CATTLE' named entity 'HEPATITIS' named entity 'REPORTED' named entity 'REPLICATE' named entity 'HEALTHY' named entity 'TISSUES' named entity 'CHINA' named entity 'REPRESSION' named entity 'AVASTROVIRUS' named entity 'EXPERIMENTAL INFECTION' named entity 'CHICKENS' named entity 'EXAMINATION' named entity 'CHARACTERIZED' named entity 'ISOLATED' named entity 'HUMANS' named entity 'CAUSE' named entity 'ASTROVIRUS' named entity 'ANIMALS' named entity 'RNA' named entity 'REVEALED' named entity 'CLINICAL SIGNS' named entity 'VIRUS' named entity 'MORTALITY' named entity 'GENOMIC' named entity 'REPLICATED' named entity 'GROWTH' named entity 'GOOSE' named entity 'CAUSING' named entity 'RELATED' named entity 'EMBRYOS' named entity 'ENCEPHALITIS' named entity 'COMPLETE' named entity 'DESIGNATED' named entity 'TIME' named entity 'URATE' named entity 'VISCERAL' named entity 'GENOME SEQUENCE' named entity 'ISOLATE' named entity 'CHARACTERIZATION' named entity 'ASTROVIRUS' named entity 'CAUSING' named entity 'DOMESTIC' named entity 'KNOWN' named entity 'OUR' named entity 'STUDY' named entity 'SHANDONG PROVINCE' named entity 'DISTINCT' named entity 'INFECTED' named entity 'DISTINCT FROM'

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