About: Molecular Distance to Health Transcriptional Score and Disease Severity in Children Hospitalized With Community-Acquired Pneumonia

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Molecular Distance to Health Transcriptional Score and Disease Severity in Children Hospitalized With Community-Acquired Pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Distance to Health Transcriptional Score and Disease Severity in Children Hospitalized With Community-Acquired Pneumonia
Creator	Tenenbaum, Tobias Mejias, Asuncion Ramilo, Octavio Marcon, Mario Moore-Clingenpeel, Melissa Cohen, Daniel Lee, Jan Bauer, Margaret Suárez, Nicolás Wallihan, Rebecca Women's And Children's Hospital, K
Source	Medline; PMC
abstract	Background: Community-acquired pneumonia (CAP) is a leading cause of hospitalization and mortality in children. Diagnosis remains challenging and there are no reliable tools to objectively risk stratify patients or predict clinical outcomes. Molecular distance to health (MDTH) is a genomic score that measures the global perturbation of the transcriptional profile and may help classify patients by disease severity. We evaluated the value of MDTH to assess disease severity in children hospitalized with CAP. Methods: Children hospitalized with CAP and matched healthy controls were enrolled in a prospective observational study. Blood samples were obtained for transcriptome analyses within 24 h of hospitalization. MDTH scores were calculated to assess disease severity and correlated with laboratory markers, such as white blood cell count, c-reactive protein (CRP), and procalcitonin (PCT), and clinical outcomes, including duration of fever and duration of hospitalization (LOS). Univariate and multivariable logistic regression were applied to assess factors associated with LOS and duration of fever after hospitalization. Results: Among children hospitalized with CAP (n = 152), pyogenic bacteria (PB) were detected in 16 (11%), Mycoplasma pneumoniae was detected in 41 (28%), respiratory viruses (RV) alone were detected in 78 (51%), and no pathogen was detected in 17 (11%) children. Statistical group comparisons identified 6,726 genes differentially expressed in patients with CAP vs. healthy controls (n = 39). Children with confirmed PB had higher MDTH scores than those with RV (p < 0.05) or M. pneumoniae (p < 0.01) detected alone. CRP (r = 0.39, p < 0.0001), PCT (r = 0.39, p < 0.0001), and MDTHs (r = 0.24, p < 0.01) correlated with duration of fever, while only MDTHs correlated with LOS (r = 0.33, p < 0.0001). Unadjusted analyses showed that both higher CRP and MDTHs were associated with longer LOS (OR 1.04 [1–1.07] and 1.12 [1.04–1.20], respectively), however, only MDTH remained significant when adjusting for other covariates (aOR 1.11 [1.01–1.22]). Conclusions: In children hospitalized with CAP MDTH score measured within 24 h of admission was independently associated with longer duration of hospitalization, regardless of the pathogen detected. This suggests that transcriptional biomarkers may represent a promising approach to assess disease severity in children with CAP.
has issue date	2018-10-30(xsd:dateTime)
bibo:doi	10.3389/fcimb.2018.00382
bibo:pmid	30425971
has license	cc-by
sha1sum (hex)	f6e29e95c1b0aa88f0ebebc39c62fb3bd461be2f
schema:url	https://doi.org/10.3389/fcimb.2018.00382
resource representing a document's title	Molecular Distance to Health Transcriptional Score and Disease Severity in Children Hospitalized With Community-Acquired Pneumonia
has PubMed Central identifier	PMC6218690
has PubMed identifier	30425971
schema:publication	Front Cell Infect Microbiol
resource representing a document's body	covid:f6e29e95c1b0aa88f0ebebc39c62fb3bd461be2f#body_text
is schema:about of	named entity 'transcriptional' named entity 'patients' named entity 'leading' named entity 'Children' named entity 'VALUE' named entity 'CHILDREN HOSPITALIZED' named entity 'DISEASE SEVERITY' named entity 'CLINICAL OUTCOMES' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'TOOLS' named entity 'EVALUATED' named entity 'SCORE' named entity 'MOLECULAR' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'MOLECULAR' named entity 'MEASURES' named entity 'CHILDREN' named entity 'HEALTH' named entity 'PERTURBATION' named entity 'DISEASE SEVERITY' named entity 'GENOMIC' named entity 'TRANSCRIPTIONAL' named entity 'DISTANCE' named entity 'STRATIFY' named entity 'DISTANCE' named entity 'RELIABLE' named entity 'PATIENTS' named entity 'SCORE' named entity 'LEADING' named entity 'CLASSIFY' named entity 'GLOBAL' named entity 'MORTALITY' named entity 'RISK' named entity 'MDTH' named entity 'PROFILE' named entity 'HEALTH' named entity 'HELP' named entity 'CAP' named entity 'ASSESS' named entity 'BACKGROUND' named entity 'HOSPITALIZATION' named entity 'TRANSCRIPTIONAL' named entity 'PREDICT' named entity 'CAUSE' named entity 'DIAGNOSIS' named entity 'CHILDREN HOSPITALIZED' named entity 'IS A' covid:arg/f6e29e95c1b0aa88f0ebebc39c62fb3bd461be2f named entity 'patients' named entity 'stratify' named entity 'objectively' named entity 'CAP' named entity 'Pneumonia' named entity 'clinical outcomes' named entity 'tuberculosis' named entity 'viruses' named entity 'transcriptional' named entity 'rhinovirus' named entity 'CRP' named entity 'observational study' named entity 'human bocavirus' named entity 'noninfectious' named entity 'respiratory failure' named entity 'CAP' named entity 'transcriptional' named entity 'fever' named entity 'pleural fluid' named entity 'bronchiolitis' named entity 'morbidity' named entity 'CAP' named entity 'FIGURE 1'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software