About: Palmitoylation of the Alphacoronavirus TGEV spike protein S is essential for incorporation into virus-like particles but dispensable for S

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About: Palmitoylation of the Alphacoronavirus TGEV spike protein S is essential for incorporation into virus-like particles but dispensable for S–M interaction Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Palmitoylation of the Alphacoronavirus TGEV spike protein S is essential for incorporation into virus-like particles but dispensable for S–M interaction
Creator	Schwegmann-Weßels, Christel Veit, Michael Eschke, Kathrin Gelhaus, Sandra Thaa, Bastian
Source	Elsevier; Medline; PMC
abstract	Abstract The spike protein S of coronaviruses contains a highly conserved cytoplasmic cysteine-rich motif adjacent to the transmembrane region. This motif is palmitoylated in the Betacoronaviruses MHV and SARS-CoV. Here, we demonstrate by metabolic labeling with [3H]-palmitic acid that the S protein of transmissible gastroenteritis coronavirus (TGEV), an Alphacoronavirus, is palmitoylated as well. This is relevant for TGEV replication as virus growth was compromised by the general palmitoylation inhibitor 2-bromopalmitate. Mutation of individual cysteine clusters in the cysteine-rich motif of S revealed that all cysteines must be replaced to abolish acylation and incorporation of S into virus-like particles (VLP). Conversely, the interaction of S with the M protein, essential for VLP incorporation of S, was not impaired by lack of palmitoylation. Thus, palmitoylation of the S protein of Alphacoronaviruses is dispensable for S–M interaction, but required for the generation of progeny virions.
has issue date	2014-09-30(xsd:dateTime)
bibo:doi	10.1016/j.virol.2014.07.035
bibo:pmid	25113909
has license	els-covid
sha1sum (hex)	f6e097f166a4b87a2a32f7afa7b399e8b70ac1b5
schema:url	https://doi.org/10.1016/j.virol.2014.07.035
resource representing a document's title	Palmitoylation of the Alphacoronavirus TGEV spike protein S is essential for incorporation into virus-like particles but dispensable for S–M interaction
has PubMed Central identifier	PMC7112097
has PubMed identifier	25113909
schema:publication	Virology
resource representing a document's body	covid:f6e097f166a4b87a2a32f7afa7b399e8b70ac1b5#body_text
is schema:about of	named entity 'compromised' named entity 'interaction' named entity 'incorporation' covid:arg/f6e097f166a4b87a2a32f7afa7b399e8b70ac1b5 named entity 'BUT' named entity 'TGEV' named entity 'CYSTEINE' named entity 'VIRIONS' named entity 'ALPHACORONAVIRUS' named entity '3 H' named entity 'ESSENTIAL' named entity 'HERE' named entity 'INTERACTION' named entity 'INDIVIDUAL' named entity 'PALMITOYLATION' named entity 'CLUSTERS' named entity 'CONSERVED' named entity 'GENERATION' named entity 'MHV' named entity 'PROGENY' named entity 'GROWTH' named entity 'S PROTEIN' named entity 'BUT' named entity 'ESSENTIAL' named entity 'ALPHACORONAVIRUS' named entity 'VIRUS-LIKE PARTICLES' named entity 'SPIKE PROTEIN' named entity 'PROTEIN ' named entity 'ADJACENT TO' named entity 'IMPAIRED' named entity 'REPLACED' named entity 'PALMITOYLATION' named entity 'PROTEIN S' named entity 'INTERACTION' named entity 'PALMITOYLATED' named entity 'GENERAL' named entity 'SARS-COV' named entity 'TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS' named entity 'MOTIF' named entity 'BETACORONAVIRUSES' named entity 'ACYLATION' named entity 'RICH' named entity 'SPIKE PROTEIN' named entity 'VLP' named entity 'CORONAVIRUSES' named entity 'M PROTEIN' named entity '2-BROMOPALMITATE' named entity 'CONTAINS' named entity 'AS VIRUS' named entity 'LACK' named entity 'METABOLIC LABELING' named entity 'CYTOPLASMIC' named entity 'VIRUS-LIKE PARTICLES' named entity 'RELEVANT' named entity 'TRANSMEMBRANE REGION' named entity 'MUTATION' named entity 'PALMITIC ACID' named entity 'INHIBITOR' named entity 'REPLICATION' named entity 'REQUIRED' named entity 'PROTEIN S' named entity 'REVEALED' named entity 'HIGHLY' named entity 'cysteine' named entity 'labeling' named entity 'coronavirus' named entity 'Alphacoronavirus' named entity 'protein' named entity 'M protein' named entity 'protein S' named entity 'interaction' named entity 'virus' named entity 'spike protein' named entity 'Alphacoronavirus' named entity 'palmitoylated' named entity 'palmitoylation' named entity 'virus-like particles'

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