About: Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation

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About: Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation
Creator	Rha, Brian Hassan, Ferdaus Selvarangan, Rangaraj Nyquist, Ann-Christine Midgley, Claire Feikin, Daniel Watson, John Curns, Aaron Schneider, Eileen Conover, Craig Leshem, Eyal Gray, Samantha Hoferka, Stacey Johnson, Daniel Miller, Lisa Obringer, Emily Patel, Ajanta Patel, Megan Turabelidze, George Pallansch, Mark Watson, J Rogers, Shannon Pallansch, M Gerber, Susan Dominguez, Samuel Feikin, D Gerber, S Leshem, E Brown, Betty Curns, A Group, Working Hassan, F Jackson, M Jackson, Mary Midgley, C Nichols, Janell Nix, Allan Oberste, Steven Rogers, S Schneider, E Schuster, J Schuster, Jennifer Selvarangan, R Seward, J Seward, Jane
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Enterovirus D68 (EV-D68) has been infrequently reported historically, and is typically associated with isolated cases or small clusters of respiratory illness. Beginning in August, 2014, increases in severe respiratory illness associated with EV-D68 were reported across the USA. We aimed to describe the clinical, epidemiological, and laboratory features of this outbreak, and to better understand the role of EV-D68 in severe respiratory illness. METHODS: We collected regional syndromic surveillance data for epidemiological weeks 23 to 44, 2014, (June 1 to Nov 1, 2014) and hospital admissions data for epidemiological weeks 27 to 44, 2014, (June 29 to Nov 1, 2014) from three states: Missouri, Illinois and Colorado. Data were also collected for the same time period of 2013 and 2012. Respiratory specimens from severely ill patients nationwide, who were rhinovirus-positive or enterovirus-positive in hospital testing, were submitted between Aug 1, and Oct 31, 2014, and typed by molecular sequencing. We collected basic clinical and epidemiological characteristics of EV-D68 cases with a standard data collection form submitted with each specimen. We compared patients requiring intensive care with those who did not, and patients requiring ventilator support with those who did not. Mantel-Haenszel χ(2) tests were used to test for statistical significance. FINDINGS: Regional and hospital-level data from Missouri, Illinois, and Colorado showed increases in respiratory illness between August and September, 2014, compared with in 2013 and 2012. Nationwide, 699 (46%) of 1529 patients tested were confirmed as EV-D68. Among the 614 EV-D68-positive patients admitted to hospital, age ranged from 3 days to 92 years (median 5 years). Common symptoms included dyspnoea (n=513 [84%]), cough (n=500 [81%]), and wheezing (n=427 [70%]); 294 (48%) patients had fever. 338 [59%] of 574 were admitted to intensive care units, and 145 (28%) of 511 received ventilator support; 322 (52%) of 614 had a history of asthma or reactive airway disease; 200 (66%) of 304 patients with a history of asthma or reactive airway disease required intensive care compared with 138 (51%) of 270 with no history of asthma or reactive airway disease (p=0·0004). Similarly, 89 (32%) of 276 patients with a history of asthma or reactive airway disease required ventilator support compared with 56 (24%) of 235 patients with no history of asthma or reactive airway disease (p=0·039). INTERPRETATION: In 2014, EV-D68 caused widespread severe respiratory illness across the USA, disproportionately affecting those with asthma. This unexpected event underscores the need for robust surveillance of enterovirus types, enabling improved understanding of virus circulation and disease burden. FUNDING: None.
has issue date	2015-11-01(xsd:dateTime)
bibo:doi	10.1016/s2213-2600(15)00335-5
bibo:pmid	26482320
has license	green-oa
sha1sum (hex)	f6de44deb595a29919640250d3346522df4a9b76
schema:url	https://doi.org/10.1016/s2213-2600%2815%2900335-5
resource representing a document's title	Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation
has PubMed Central identifier	PMC5693332
has PubMed identifier	26482320
schema:publication	The Lancet Respiratory Medicine
resource representing a document's body	covid:f6de44deb595a29919640250d3346522df4a9b76#body_text
is schema:about of	named entity 'INVESTIGATION' named entity 'isolated' named entity 'respiratory illness' named entity 'ENTEROVIRUS D68' named entity 'SMALL' named entity 'ASSOCIATED WITH' named entity 'AUGUST' named entity 'ENTEROVIRUS D68' named entity 'ASSOCIATED WITH' named entity 'CLUSTERS' named entity 'ACROSS' named entity 'ISOLATED CASES' named entity 'EPIDEMIOLOGICAL' named entity 'USA' named entity 'RESPIRATORY ILLNESS' named entity 'BEGINNING' named entity 'SEVERE' named entity 'SEVERE' named entity 'DESCRIPTIVE' named entity 'OUTBREAK' named entity 'INFREQUENTLY' named entity 'D68' named entity 'BACKGROUND' named entity 'INCREASES' named entity 'RESPIRATORY ILLNESS' named entity 'REPORTED' named entity 'typically' named entity 'Enterovirus D68' named entity 'EV-D68' named entity 'EV-D68' named entity 'respiratory illness' named entity 'respiratory illness' named entity 'enterovirus D68' named entity 'nationwide outbreak' named entity 'respiratory illness' named entity 'reactive airway disease' named entity 'Cough'

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