About: Worldwide ACE (I/D) polymorphism may affect COVID-19 recovery rate: an ecological meta-regression

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About: Worldwide ACE (I/D) polymorphism may affect COVID-19 recovery rate: an ecological meta-regression Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Worldwide ACE (I/D) polymorphism may affect COVID-19 recovery rate: an ecological meta-regression
Creator	Ahi, Salma Farshid Javdani, • Fereydoni, Mostafa Foroughian, Mahdi Hatami, Naser Hosseini, Ava Kalani, Navid Keshavarz, Pouyan Sadeghinikoo, Alireza
Source	Medline; PMC
abstract	With the emergence of the Novel Coronavirus (2019-nCoV), researchers worldwide have started detecting the probable pathogenesis of the disease. The renin–angiotensin system (RAS) and angiotensin-converting enzymes have received a good deal of attention as possible pathways involved in 2019-nCoV pathogenesis. As the experiments seeking to find potential medications acting on these pathways are being conducted in the early phases, having an ecological worldview on the relationship between the prevalence of COVID-19 disease and the genetic differences in the genes involved in the RAS system could be valuable for the field. In this regard, we conducted a meta-analysis study of the prevalence of ACE (I/D) genotype in countries most affected by the COVID-19. In the meta-analysis, 48,758 healthy subjects from 30 different countries were evaluated in 116 studies, using the Comprehensive Meta-analysis software. The I/D allele frequency ratio was pooled by a random-effect model. The COVID-19 prevalence data of death and recovery rates were evaluated as the latitudes for the meta-regression analysis. Our results demonstrated that with the increase of the I/D allele frequency ratio, the recovery rate significantly increased (point estimate: 0.48, CI 95%: 0.05–0.91, p = 0.027). However, there was no significant difference in the case of death rate (point estimate: 1.74, CI 95%: 4.5–1.04, p = 0.22). This ecological perspective coupled with many limitations does not provide a direct clinical relevance between the COVID-19 and RAS system, but it shows potential pathophysiological associations. Our results raise concerns about ethnic and genetic differences that could affect the effectiveness of the currently investigated RAS-associated medications in different regions.
has issue date	2020-06-15(xsd:dateTime)
bibo:doi	10.1007/s12020-020-02381-7
bibo:pmid	32542429
has license	no-cc
sha1sum (hex)	f6b9d4c6a11687a7d24a5ca157a082d77e9ab211
schema:url	https://doi.org/10.1007/s12020-020-02381-7
resource representing a document's title	Worldwide ACE (I/D) polymorphism may affect COVID-19 recovery rate: an ecological meta-regression
has PubMed Central identifier	PMC7294766
has PubMed identifier	32542429
schema:publication	Endocrine
resource representing a document's body	covid:f6b9d4c6a11687a7d24a5ca157a082d77e9ab211#body_text
is schema:about of	named entity 'PROBABLE' named entity 'COVID-19' named entity 'ENZYMES' named entity '2019-nCoV' named entity 'COVID-19 disease' named entity 'RAS' named entity 'allele frequency' named entity 'ACE' named entity 'death rate' named entity 'pathogenesis' named entity 'ACE2' named entity 'RAS' named entity 'allele frequency' named entity 'Africa' named entity 'COVID' named entity 'gene polymorphism' named entity 'COVID' named entity 'COVID-19 pandemic' named entity 'somatic' named entity 'death rates' named entity 'type II alveolar cells' named entity 'genetic variations' named entity 'renin-angiotensin' named entity 'pneumonia' named entity 'Coronaviridae' named entity 'Europe' named entity 'protein' named entity 'China' named entity 'allele' named entity 'ACE2' named entity 'allele' named entity 'coronavirus 2019' named entity 'ACE2' named entity 'allele' named entity 'polymorphism' named entity 'allele' named entity 'COVID' named entity 'South Korea' named entity 'meta-analyses' named entity 'receptor' named entity 'COVID' named entity 'Denmark' named entity 'inverse method' named entity 'lung tissue' named entity 'common cold' named entity 'ACE I/D' named entity 'allele frequency' named entity 'genotype' named entity 'virus' named entity 'HCV' named entity 'receptor' named entity 'allele' named entity 'coding regions' named entity 'allele' named entity 'total death' named entity 'COVID-19' named entity 'allele' named entity 'allele' named entity 'coronavirus' named entity 'gene' named entity 'death rates' named entity 'Japan' named entity 'allele frequency' named entity 'allele' named entity 'ACE I/D' named entity 'ACE2' named entity 'ISI' named entity '1, 2' named entity '1.04' named entity 'ACE I/D' named entity 'ACE2 receptor' named entity 'genotypes' named entity 'enveloped viruses'

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