About: Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study
Creator	Wang, David Grimwood, Keith Nissen, Michael Sloots, Theo Bialasiewicz, Seweryn Whiley, David Cook, Anne Lambert, Stephen Mackay, Ian Maguire, Frances Ware, Robert
Source	PMC
abstract	INTRODUCTION: Even in developed economies infectious diseases remain the most common cause of illness in early childhood. Our current understanding of the epidemiology of these infections is limited by reliance on data from decades ago performed using low-sensitivity laboratory methods, and recent studies reporting severe, hospital-managed disease. METHODS AND ANALYSIS: The Observational Research in Childhood Infectious Diseases (ORChID) study is an ongoing study enrolling a dynamic birth cohort to document the community-based epidemiology of viral respiratory and gastrointestinal infections in early childhood. Women are recruited antenatally, and their healthy newborn is followed for the first 2 years of life. Parents keep a daily symptom diary for the study child, collect a weekly anterior nose swab and dirty nappy swab and complete a burden diary when a child meets pre-defined illness criteria. Specimens will be tested for a wide range of viruses by real-time PCR assays. Primary analyses involves calculating incidence rates for acute respiratory illness (ARI) and acute gastroenteritis (AGE) for the cohort by age and seasonality. Control material from children when they are without symptoms will allow us to determine what proportion of ARIs and AGE can be attributed to specific pathogens. Secondary analyses will assess the incidence and shedding duration of specific respiratory and gastrointestinal pathogens. ETHICS AND DISSEMINATION: This study is approved by The Human Research Ethics Committees of the Children's Health Queensland Hospital and Health Service, the Royal Brisbane and Women's Hospital and The University of Queensland. TRIAL REGISTRATION: clinicaltrials.gov NCT01304914.
has issue date	2012-10-31(xsd:dateTime)
bibo:doi	10.1136/bmjopen-2012-002134
bibo:pmid	23117571
has license	cc-by-nc
sha1sum (hex)	f6b7e95bba8fc989701322484c6318774eb1ed6b
schema:url	https://doi.org/10.1136/bmjopen-2012-002134
resource representing a document's title	Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study
has PubMed Central identifier	PMC3547315
has PubMed identifier	23117571
schema:publication	BMJ Open
resource representing a document's body	covid:f6b7e95bba8fc989701322484c6318774eb1ed6b#body_text
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