About: Risk Factors for Mortality and Respiratory Support in Elderly Patients Hospitalized with COVID-19 in Korea

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Risk Factors for Mortality and Respiratory Support in Elderly Patients Hospitalized with COVID-19 in Korea
Creator	Huh, Kyungmin Chang, Hyun-Ha Kim, Hyun Lee, Ji Peck, Kyong
Source	Medline; PMC
abstract	BACKGROUND: The mortality risk of coronavirus disease 2019 (COVID-19) is higher in patients with older age, and many elderly patients are reported to require advanced respiratory support. METHODS: We reviewed medical records of 98 patients aged ≥ 65 years who were hospitalized with COVID-19 during a regional outbreak in Daegu/Gyeongsangbuk-do province of Korea. The outcome measures were in-hospital mortality and the treatment with mechanical ventilation (MV) or high-flow nasal cannula (HFNC). RESULTS: The median age of the patients was 72 years; 55.1% were female. Most (74.5%) had at least one underlying condition. Overall case fatality rate (CFR) was 20.4%, and median time to death after admission was 8 days. The CFR was 6.1% among patients aged 65–69 years, 22.7% among those aged 70–79 years, and 38.1% among those aged ≥ 80 years. The CFR among patients who required MV was 43.8%, and the proportion of patients received MV/HFNC was 28.6%. Nosocomial acquisition, diabetes, chronic lung diseases, and chronic neurologic diseases were significant risk factors for both death and MV/HFNC. Hypotension, hypoxia, and altered mental status on admission were also associated with poor outcome. CRP > 8.0 mg/dL was strongly associated with MV/HFNC (odds ratio, 26.31; 95% confidence interval, 7.78–88.92; P < 0.001), and showed better diagnostic characteristics compared to commonly used clinical scores. CONCLUSION: Patients aged ≥ 80 years had a high risk of requiring MV/HFNC, and mortality among those severe patients was very high. Severe initial presentation and laboratory abnormalities, especially high CRP, were identified as risk factors for mortality and severe hospital course.
has issue date	2020-06-11(xsd:dateTime)
bibo:doi	10.3346/jkms.2020.35.e223
bibo:pmid	32537957
has license	cc-by-nc
sha1sum (hex)	f66990ad006a3cce472bc8ef5a618704eba7b5af
schema:url	https://doi.org/10.3346/jkms.2020.35.e223
resource representing a document's title	Risk Factors for Mortality and Respiratory Support in Elderly Patients Hospitalized with COVID-19 in Korea
has PubMed Central identifier	PMC7295602
has PubMed identifier	32537957
schema:publication	J Korean Med Sci
resource representing a document's body	covid:f66990ad006a3cce472bc8ef5a618704eba7b5af#body_text
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