About: Ribosomal frameshifting in the yeast retrotransposon Ty: tRNAs induce slippage on a 7 nucleotide minimal site

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About: Ribosomal frameshifting in the yeast retrotransposon Ty: tRNAs induce slippage on a 7 nucleotide minimal site Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Ribosomal frameshifting in the yeast retrotransposon Ty: tRNAs induce slippage on a 7 nucleotide minimal site
Creator	Belcourt,'t, Michael Farabaught, Philip
topic	covid:f65bd12c7c03725e764af2781e0142d6ea2a22c9#this
source	Elsevier; Medline; PMC
abstract	Abstract Ribosomal frameshifting regulates expression of the TYB gene of yeast Ty retrotransposons. We previously demonstrated that a 14 nucleotide sequence conserved between two families of Ty elements was necessary and sufficient to support ribosomal frameshifting. This work demonstrates that only 7 of these 14 nucleotides are needed for normal levels of frameshifting. Any change to the sequence CUU-AGG-C drastically reduces frameshifting; this suggests that two specific tRNAs, tRNALeu UAG and tRNAArg CCU, are involved in the event. Our tRNA overproduction data suggest that a leucyl-tRNA, probably tRNALeu UAG, an unusual leucine isoacceptor that recognizes all six leucine codons, slips from CUU-Leu onto UUA-Leu (in the +1 reading frame) during a translational pause at the AGG-Arg codon induced by the low availability of tRNAArg CCU, encoded by a single-copy essential gene. Frameshifting is also directional and reading frame specific. Interestingly, frameshifting is inhibited when the “slip” CUU codon is located three codons downstream, but not four or more codons downstream, of the translational initiation codon.
has issue date	1990-07-27(xsd:dateTime)
bibo:doi	10.1016/0092-8674(90)90371-k
bibo:pmid	2164889
has license	els-covid
sha1sum (hex)	f65bd12c7c03725e764af2781e0142d6ea2a22c9
schema:url	https://doi.org/10.1016/0092-8674%2890%2990371-k
resource representing a document's title	Ribosomal frameshifting in the yeast retrotransposon Ty: tRNAs induce slippage on a 7 nucleotide minimal site
has PubMed Central identifier	PMC7133245
has PubMed identifier	2164889
schema:publication	Cell
resource representing a document's body	covid:f65bd12c7c03725e764af2781e0142d6ea2a22c9#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/f65bd12c7c03725e764af2781e0142d6ea2a22c9
is schema:about of	named entity 'Site' named entity 'SITE' named entity 'MINIMAL' named entity 'YEAST' named entity 'RIBOSOMAL' named entity 'NUCLEOTIDE' named entity 'RETROTRANSPOSON' named entity 'A 7' named entity 'INDUCE' named entity 'Yeast' named entity 'Ribosomal Frameshifting' named entity 'Nucleotide' named entity 'retroviral' named entity 'frameshift' named entity 'termination codons' named entity 'reading frame' named entity 'frameshifting' named entity 'retroviruses' named entity 'codon' named entity '5'end' named entity 'nucleotides' named entity 'termination codon' named entity 'frameshifting' named entity 'frameshift' named entity 'yeast' named entity 'yeast' named entity 'gene' named entity 'anticodon' named entity 'frameshifting' named entity 'codons' named entity 'genetic loci' named entity 'cloned' named entity 'gene' named entity 'tRNAs' named entity 'yeast' named entity 'in-frame' named entity 'frameshift' named entity 'Gly' named entity 'tRNA' named entity 'nucleotide' named entity 'nucleotide' named entity 'tRNA' named entity 'HIV' named entity 'E. coli' named entity 'AUG codon' named entity 'oligonucleotides' named entity 'termination codons' named entity 'frameshift' named entity 'phenylalanine' named entity 'Phe' named entity 'frameshifting' named entity 'frameshift' named entity 'CGG' named entity 'codons' named entity 'enzyme activity' named entity 'codons' named entity 'tRNA' named entity 'lacZ' named entity 'frameshifting' named entity 'CUU' named entity 'MMTV' named entity 'yeast' named entity 'CUU' named entity 'termination codons' named entity 'Frameshifting' named entity 'Applied Biosystems' named entity 'RNA sequence' named entity 'cloned' named entity 'wild-type' named entity 'CUU' named entity 'reading frame' named entity 'CUU' named entity 'CUU' named entity 'yeast' named entity 'frameshifting' named entity 'reading frame' named entity 'codons' named entity 'ribosome'

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