About: Characterization of the complete genome, antigenicity, pathogenicity, tissue tropism, and shedding of a recombinant avian infectious bronchitis virus with a ck/CH/LJL/140901-like backbone and an S2 fragment from a 4/91-like virus

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About: Characterization of the complete genome, antigenicity, pathogenicity, tissue tropism, and shedding of a recombinant avian infectious bronchitis virus with a ck/CH/LJL/140901-like backbone and an S2 fragment from a 4/91-like virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of the complete genome, antigenicity, pathogenicity, tissue tropism, and shedding of a recombinant avian infectious bronchitis virus with a ck/CH/LJL/140901-like backbone and an S2 fragment from a 4/91-like virus
Creator	Han, Zongxi Liu, Shengwang Chen, Yuqiu Zhao, Yan Sun, Junfeng Zhao, Wenjun Jiang, Lei
Source	Elsevier; Medline; PMC
abstract	Abstract In this study, we isolated an infectious bronchitis virus, designated I1101/16, from broiler breeders in China. Analysis of the S1 gene showed that isolate I1101/16 was genetically close to strain ck/CH/LJL/140901, which belongs to the TW I genotype (also known as lineage GI-7 based on the recent IBV classification), however the S2 gene showed genetic diversity comparing to that of S1 gene. Comparison of the genomic sequences showed that the genome of isolate I1101/16 was similar to that of strain ck/CH/LJL/140901 from the 5′ end of the genome to the 5′ end of the S2 gene and from the 5′ end of the 3a gene to the end of the genome, whereas the remaining parts of the genome sequences were more closely related to those of strain 4/91 than those of ck/CH/LJL/140901, thereby suggesting that recombination might have occurred during the origin of the virus. SimPlot and Bootscan analysis of the complete genomic sequence confirmed this hypothesis, where it showed that isolate I1101/16 arose through recombination events between ck/CH/LJL/140901- and 4/91-like viruses. Isolate I1101/16 and strain ck/CH/LJL/140901 shared identical amino acids in almost all five of their B cell epitopes, but the two viruses had a serotype relatedness value of 65, which is well below 80, i.e., the lower cutoff value for viruses of the same serotype. In addition, pathogenicity tests demonstrated that isolate I1101/16 was more pathogenic to 1-day-old specific-pathogen-free chickens than strain ck/CH/LJL/140901, according to analysis of the clinical signs, whereas strain ck/CH/LJL/140901 exhibited prolonged replication and shedding after challenge compared with isolate I1101/16. This study did not provide evidence that recombination can directly alter the antigenicity, virulence, replication, shedding, and tissue tropism of a virus, but it did show that recombination events are likely to be major determinants of viral evolution.
has issue date	2018-01-15(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2017.11.007
bibo:pmid	29141204
has license	els-covid
sha1sum (hex)	f63d830bc5c88a85c5cec59a4ba2c5cbc46f5dc3
schema:url	https://doi.org/10.1016/j.virusres.2017.11.007
resource representing a document's title	Characterization of the complete genome, antigenicity, pathogenicity, tissue tropism, and shedding of a recombinant avian infectious bronchitis virus with a ck/CH/LJL/140901-like backbone and an S2 fragment from a 4/91-like virus
has PubMed Central identifier	PMC7114561
has PubMed identifier	29141204
schema:publication	Virus Research
resource representing a document's body	covid:f63d830bc5c88a85c5cec59a4ba2c5cbc46f5dc3#body_text
is schema:about of	named entity 'tissue tropism' named entity 'COMPLETE' named entity 'AVIAN INFECTIOUS BRONCHITIS VIRUS' named entity 'PATHOGENICITY' named entity 'TISSUE TROPISM' named entity 'SHEDDING' named entity 'BACKBONE' named entity 'GENOME' named entity 'CHARACTERIZATION' named entity 'LIKE' named entity 'RECOMBINANT' named entity 'ANTIGENICITY' named entity 'VIRUS' named entity 'FRAGMENT' named entity 'shedding' named entity 'genome' named entity 'virus' named entity 'serotypes' named entity 'Multiple Alignment' named entity 'UTR' named entity 'viral antigens' named entity 'nasopharyngeal' named entity 'poultry industry' named entity 'chicken' named entity 'White Leghorn' named entity 'membrane fusion' named entity 'monoclonal antibody' named entity 'Viral titers' named entity 'virus' named entity 'virus' named entity 'IBV' named entity 'virulence' named entity 'virus' named entity 'SimPlot' named entity 'antigenic' named entity 'Australia' named entity 'Invitrogen Corporation' named entity 'watery eyes' named entity 'nucleotide' named entity 'China' named entity 'kidneys' named entity 'virus' named entity 'IBV' named entity 'gene' named entity 'gene' named entity 'pathogenicity' named entity 'host cell receptor' named entity 'SimPlot' named entity 'genome sequences' named entity 'gene' named entity 'MAFFT' named entity 'virus' named entity 'viral replication' named entity 'IBV' named entity 'sneezing' named entity 'TRIzol' named entity 'recombination events' named entity 'infectivity' named entity 'nTW' named entity 'spike protein' named entity 'nucleotide sequences' named entity 'recombination' named entity 'virus' named entity 'phosphate-buffered saline' named entity 'antigenic' named entity 'tropisms' named entity 'virus' named entity 'Italy' named entity 'genome' named entity 'antigenic' named entity 'serotype' named entity 'LDL' named entity 'gene' named entity 'Fast Fourier Transformation' named entity 'poultry'

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