About: Common variants of chemokine receptor gene CXCR3 and its ligands CXCL10 and CXCL11 associated with vascular permeability of dengue infection in peninsular Malaysia

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About: Common variants of chemokine receptor gene CXCR3 and its ligands CXCL10 and CXCL11 associated with vascular permeability of dengue infection in peninsular Malaysia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Common variants of chemokine receptor gene CXCR3 and its ligands CXCL10 and CXCL11 associated with vascular permeability of dengue infection in peninsular Malaysia
Creator	Hoh, B Khairudin, N Lee Christopher, K Mahiran, M Masliza, Z Rafidah-Hanim, S Sazaly, A Sim Benedict, L Umi-Shakina, H Zaiharina, M Zuraihan, Z
Source	Elsevier; Medline; PMC
abstract	Abstract Dengue causes significantly more human disease than any other arboviruses. It causes a spectrum of illness, ranging from mild self-limited fever, to severe and fatal dengue hemorrhagic fever, as evidenced by vascular leakage and multifactorial hemostatic abnormalities. There is no specific treatment available till date. Evidence shows that chemokines CXCL10, CXCL11 and their receptor CXCR3 are involved in severity of dengue, but their genetic association with the susceptibility of vascular leakage during dengue infection has not been reported. We genotyped 14 common variants of these candidate genes in 176 patients infected with dengue. rs4859584 and rs8878 (CXCL10) were significantly associated with vascular permeability of dengue infection (P <0.05); while variants of CXCL11 showed moderate significance of association (P =0.0527). Haplotype blocks were constructed for genes CXCL10 and CXCL11 (5 and 7 common variants respectively). Haplotype association tests performed revealed that, “CCCCA” of gene CXCL10 and “AGTTTAC” of CXCL11 were found to be significantly associated with vascular leakage (P =0.0154 and 0.0366 respectively). In summary, our association study further strengthens the evidence of the involvement of CXCL10 and CXCL11 in the pathogenesis of dengue infection.
has issue date	2015-06-30(xsd:dateTime)
bibo:doi	10.1016/j.humimm.2015.03.019
bibo:pmid	25858769
has license	els-covid
sha1sum (hex)	f61afe136befbbe424ddd37c5b92411741d705d8
schema:url	https://doi.org/10.1016/j.humimm.2015.03.019
resource representing a document's title	Common variants of chemokine receptor gene CXCR3 and its ligands CXCL10 and CXCL11 associated with vascular permeability of dengue infection in peninsular Malaysia
has PubMed Central identifier	PMC7115693
has PubMed identifier	25858769
schema:publication	Human Immunology
resource representing a document's body	covid:f61afe136befbbe424ddd37c5b92411741d705d8#body_text
is schema:about of	named entity 'receptor' named entity 'infection' named entity 'multifactorial' named entity 'genes' named entity 'Evidence' named entity 'patients' named entity 'abnormalities' named entity 'hemostatic' named entity 'CXCL10' named entity 'MODERATE' named entity 'VASCULAR PERMEABILITY' named entity 'CXCL11' named entity 'DENGUE INFECTION' named entity '28P' named entity 'CONSTRUCTED' named entity 'DATE' named entity 'REPORTED' named entity 'ASSOCIATION' named entity 'SPECTRUM' named entity 'VARIANTS' named entity '0.05' named entity 'PATIENTS' named entity 'SEVERE' named entity 'LEAKAGE' named entity 'EVIDENCE' named entity 'HEMOSTATIC' named entity 'GENETIC ASSOCIATION' named entity 'SUSCEPTIBILITY' named entity 'THESE' named entity 'CXCL10' named entity 'CAUSES' named entity 'TREATMENT AVAILABLE' named entity 'INVOLVED' named entity 'MILD' named entity 'TILL' named entity 'SEVERITY' named entity 'CHEMOKINES' named entity 'FEVER' named entity 'REVEALED' named entity 'ASSOCIATION STUDY' named entity 'TESTS' named entity 'LIGANDS' named entity 'LIMITED' named entity 'INVOLVEMENT' named entity 'GENES' named entity 'MULTIFACTORIAL' named entity 'FATAL' named entity 'CANDIDATE GENES' named entity 'ABNORMALITIES' named entity 'EVIDENCE OF' named entity 'SUMMARY' named entity 'CHEMOKINE RECEPTOR GENE' named entity 'ITS' named entity 'DENGUE INFECTION' named entity 'CXCR3' named entity 'ASSOCIATED WITH' named entity 'VASCULAR PERMEABILITY' named entity 'COMMON' named entity 'PERFORMED' named entity 'COMMON' named entity 'ARBOVIRUSES' named entity 'SPECIFIC' named entity 'BLOCKS' named entity 'DENGUE' named entity 'THEIR' named entity 'OUR' named entity 'GENE' named entity 'ILLNESS' named entity 'SELF' named entity 'ASSOCIATED WITH' named entity 'FOUND'

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