About: Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes
Creator	Lévêque, Nicolas Chessa, Céline Garcia, Magali Pizzo, Elio Bodet, Charles Jousselin, Clément Wehbe, Michel Alva-Murillo, Nayeli Kizhakkedathu, Jayachandran
Source	Medline; PMC
abstract	Keratinocytes, the main cells of the epidermis, are the first site of replication as well as the first line of defense against many viruses such as arboviruses, enteroviruses, herpes viruses, human papillomaviruses, or vaccinia virus. During viral replication, these cells can sense virus associated molecular patterns leading to the initiation of an innate immune response composed of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. Human keratinocytes produce and secrete at least nine antimicrobial peptides: human cathelicidin LL-37, types 1–4 human β-defensins, S100 peptides such as psoriasin (S100A7), calprotectin (S100A8/9) and koebnerisin (S100A15), and RNase 7. These peptides can exert direct antiviral effects on the viral particle or its replication cycle, and indirect antiviral activity, by modulating the host immune response. The purpose of this review is to summarize current knowledge of antiviral and immunomodulatory properties of human keratinocyte antimicrobial peptides.
has issue date	2020-06-03(xsd:dateTime)
bibo:doi	10.3389/fmicb.2020.01155
bibo:pmid	32582097
has license	cc-by
sha1sum (hex)	f5fd5f08666bb99b583433b06d67800fa476afef
schema:url	https://doi.org/10.3389/fmicb.2020.01155
resource representing a document's title	Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes
has PubMed Central identifier	PMC7283518
has PubMed identifier	32582097
schema:publication	Front Microbiol
resource representing a document's body	covid:f5fd5f08666bb99b583433b06d67800fa476afef#body_text
is schema:about of	named entity 'Antimicrobial' named entity 'Antimicrobial Peptides' named entity 'peptides' named entity 'antifungal' named entity 'cysteine' named entity 'extracellular signal-regulated kinases' named entity 'β-defensins' named entity 'IL-1β' named entity 'upregulated' named entity 'phospholipase' named entity 'TLR' named entity 'S100A7' named entity 'CCR6' named entity 'intracellular' named entity 'viral entry' named entity 'A549' named entity 'ZIKV' named entity 'innate immune response' named entity 'endosomal' named entity 'keratinocyte' named entity 'proinflammatory' named entity 'PI3K/Akt' named entity 'RSV' named entity 'TLR4' named entity 'DENV' named entity 'antiviral activity' named entity 'type 16' named entity 'LL-37' named entity 'enterovirus' named entity 'RIG-I' named entity 'infection' named entity 'DCs' named entity 'Toll-Like Receptors' named entity 'Gram-positive and Gram-negative' named entity 'hBDs' named entity 'exact mechanism' named entity 'epidermis' named entity 'koebnerisin' named entity 'macrophages' named entity 'antimicrobial activity' named entity 'melanocytes' named entity 'ERK signaling' named entity 'Peptides' named entity 'TNF-α' named entity 'TNF-α' named entity 'LL-37' named entity 'DNA-dependent RNA polymerase' named entity 'peptide' named entity 'IL-6' named entity 'receptor' named entity 'CXCR4' named entity 'genome replication' named entity 'recruiting leukocytes' named entity 'S100A8' named entity 'administrated' named entity 'innate immune cell' named entity 'Pichia pastoris' named entity 'S100A7' named entity 'infection' named entity 'VZV' named entity 'receptor' named entity 'supernatant' named entity 'intracellular' named entity 'IAV' named entity 'biopsy' named entity 'cytokines' named entity 'RSV' named entity 'Nestle' named entity 'antiviral' named entity 'proinflammatory' named entity 'entry inhibitor' named entity 'IL-1β' named entity 'inflammatory response'

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