About: Pre-existing immunity against vaccine vectors

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pre-existing immunity against vaccine vectors – friend or foe?
Creator	Saxena, Manvendra Baird, Fiona Coloe, Peter Smooker, Peter Thu, Thi Van, Hao
Source	Medline; PMC
abstract	Over the last century, the successful attenuation of multiple bacterial and viral pathogens has led to an effective, robust and safe form of vaccination. Recently, these vaccines have been evaluated as delivery vectors for heterologous antigens, as a means of simultaneous vaccination against two pathogens. The general consensus from published studies is that these vaccine vectors have the potential to be both safe and efficacious. However, some of the commonly employed vectors, for example Salmonella and adenovirus, often have pre-existing immune responses in the host and this has the potential to modify the subsequent immune response to a vectored antigen. This review examines the literature on this topic, and concludes that for bacterial vectors there can in fact, in some cases, be an enhancement in immunogenicity, typically humoral, while for viral vectors pre-existing immunity is a hindrance for subsequent induction of cell-mediated responses.
has issue date	2013-01-01(xsd:dateTime)
bibo:doi	10.1099/mic.0.049601-0
bibo:pmid	23175507
has license	cc-by
sha1sum (hex)	f5bdf18567bb3760e1ce05008135f0270badbd5c
schema:url	https://doi.org/10.1099/mic.0.049601-0
resource representing a document's title	Pre-existing immunity against vaccine vectors – friend or foe?
has PubMed Central identifier	PMC3542731
has PubMed identifier	23175507
schema:publication	Microbiology
resource representing a document's body	covid:f5bdf18567bb3760e1ce05008135f0270badbd5c#body_text
is schema:about of	named entity 'foe' named entity 'FOE' named entity 'PRE-EXISTING' named entity 'FRIEND' named entity 'IMMUNITY' named entity 'VACCINE' named entity 'VECTORS' named entity 'antibody' named entity 'vector' named entity 'antigens' named entity 'antibody' named entity 'vector' named entity 'poultry industry' named entity 'Salmonella' named entity 'Listeria' named entity 'vector' named entity 'vaccination' named entity 'YFV' named entity 'serum' named entity 'mice' named entity 'viral vectors' named entity 'heterologous' named entity 'innate immunity' named entity 'opsonin' named entity 'viruses' named entity 'natural immunity' named entity 'immune responses' named entity 'virulent strain' named entity 'vector' named entity 'Listeria' named entity 'neutralizing antibodies' named entity 'clinical studies' named entity 'E. coli' named entity 'intracellular pathogen' named entity 'Salmonella' named entity 'viruses' named entity 'CD8 +' named entity 'Salmonella' named entity 'spp' named entity 'antigen' named entity 'immune responses' named entity 'serovars' named entity 'humoral responses' named entity 'genetic stability' named entity 'antibodies' named entity 'antigen' named entity 'severe acute respiratory syndrome' named entity 'antigen' named entity 'vaccine' named entity 'LPS' named entity 'vector' named entity 'serovars' named entity 'viruses' named entity 'mice' named entity 'mice' named entity 'immune responses' named entity 'immune responses' named entity 'macrophages' named entity 'Salmonella' named entity 'mice' named entity 'influenza virus' named entity 'interleukin 4' named entity 'live bacteria' named entity 'pathogens' named entity 'humoral' named entity 'vector' named entity 'vector' named entity 'upregulation' named entity 'humoral responses' named entity 'CTL' named entity 'vaccine' named entity 'Listeria' named entity 'heterologous' named entity 'mice' named entity 'Salmonella' named entity 'vaccination'

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