About: Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study

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About: Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
Creator	Cao, Bin Qu, Jiuxin Tong, Zhaohui Wang, Zheng Wang, Chen Sun, Bing Wan, Jun Ban, Chengjun He, Hangyong Li, Xuyan
Source	PMC
abstract	INTRODUCTION: Since 2008, severe cases of emerging human adenovirus type 55 (HAdV-55) in immunocompetent adults have been reported sporadically in China. The clinical features and outcomes of the most critically ill patients with severe acute respiratory distress syndrome (ARDS) caused by HAdV-55 requiring invasive mechanical ventilation (IMV) and/or extracorporeal membrane oxygenation (ECMO) are lacking. METHODS: We conducted a prospective, single-center observational study of pneumonia with ARDS in immunocompetent adults admitted to our respiratory ICU. We prospectively collected and analyzed clinical, laboratory, radiological characteristics, sequential tests of viral load in respiratory tract and blood, treatments and outcomes. RESULTS: The results for a total of five consecutive patients with severe ARDS with confirmed HAdV-55 infection were included. All five patients were immunocompetent young men with a median age of 32 years. The mean time from onset to dyspnea was 5 days. Arterial blood gas analysis at ICU admission revealed profound hypoxia. Mean partial oxygen pressure/fraction of inspired oxygen was 58.1. Mean durations from onset to a single-lobe consolidation shown on chest X-rays (CXRs) and, from the first positive CXR to bilateral multilobar lung infiltrates, were 2 days and 4.8 days, respectively. The viral load was higher than 1 × 10(8) copies in three patients and was 1 × 10(4) in one patient. It was negative in the only patient who survived. The mean duration for noninvasive positive pressure ventilation (NPPV) failure and IMV failure were 30.8 hours and 6.2 days, respectively. Four patients received venovenous ECMO. Four (80%) of the five patients died despite receiving appropriate respiratory support. CONCLUSIONS: HAdV-55 may cause severe ARDS in immunocompetent young men. Persistent high fever, dyspnea and rapid progression to respiratory failure within 2 weeks, together with bilateral consolidations and infiltrates, are the most frequent clinical manifestations of HAdV-55-induced severe ARDS. Viral load monitoring may help predict disease severity and outcome. The NPPV and IMV failure rates were very high, but ECMO may still be the respiratory support therapy of choice. TRIAL REGISTRATION: Clinicaltrials.gov NCT01585922. Registered 20 April 2012
has issue date	2014-08-12(xsd:dateTime)
bibo:doi	10.1186/s13054-014-0456-6
bibo:pmid	25112957
has license	cc-by
sha1sum (hex)	f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
schema:url	https://doi.org/10.1186/s13054-014-0456-6
resource representing a document's title	Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
has PubMed Central identifier	PMC4243941
has PubMed identifier	25112957
schema:publication	Crit Care
resource representing a document's body	covid:f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0#body_text
is schema:about of	named entity 'SEQUENTIAL' named entity 'LACKING' named entity 'VIRAL LOAD' named entity 'SINGLE' named entity 'CHINA' named entity 'ANALYZED' named entity 'INVASIVE MECHANICAL VENTILATION' named entity 'ADMITTED TO' named entity 'PATIENTS' named entity 'TESTS' named entity 'COLLECTED' named entity 'CLINICAL FEATURES' named entity 'LABORATORY' named entity 'immunocompetent' named entity 'mechanical ventilation' named entity 'critically ill' named entity 'EMERGENT' covid:arg/f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0 named entity 'CASES' named entity 'CRITICALLY ILL' named entity 'EXTRACORPOREAL MEMBRANE OXYGENATION' named entity 'ARDS' named entity 'REPORTED' named entity 'ICU' named entity 'OUTCOMES' named entity 'TREATMENTS' named entity 'OBSERVATIONAL STUDY' named entity 'ADULTS' named entity 'CHARACTERISTICS' named entity 'ADENOVIRUS TYPE' named entity 'RESPIRATORY TRACT' named entity 'ADENOVIRUS TYPE' named entity 'ADULTS' named entity 'CAUSED BY' named entity 'PROSPECTIVE OBSERVATIONAL STUDY' named entity 'IMMUNOCOMPETENT' named entity 'RESPIRATORY' named entity 'OUR' named entity 'BLOOD' named entity 'CAUSED BY' named entity 'INTRODUCTION' named entity 'CENTER' named entity 'CLINICAL' named entity 'PNEUMONIA' named entity 'SEVERE' named entity 'HUMAN ADENOVIRUS' named entity 'METHODS' named entity 'PROSPECTIVE' named entity 'IMMUNOCOMPETENT' named entity 'SPORADICALLY' named entity 'HAVE' named entity 'viral load' named entity 'human' named entity 'collected' named entity 'severe' named entity 'clinical features' named entity 'immunocompetent' named entity 'extracorporeal membrane oxygenation' named entity 'IMV' named entity 'respiratory failure' named entity 'sputum' named entity 'dyspnea' named entity 'acute phase' named entity 'immunocompetent' named entity 'nucleic acid' named entity 'respiratory failure' named entity 'phylogeny' named entity 'PEEP' named entity 'ECMO' named entity 'NPPV' named entity 'tachypnea' named entity 'ARDS'

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