About: Cryptosporidium parvum: Determination of ID50 and the dose–response relationship in experimentally challenged dairy calves

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About: Cryptosporidium parvum: Determination of ID50 and the dose–response relationship in experimentally challenged dairy calves Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cryptosporidium parvum: Determination of ID50 and the dose–response relationship in experimentally challenged dairy calves
Creator	Nydam, D Bowman, D Liotta, J Mohammed, H Wilcox, Z Zambriski, J
Source	Elsevier; Medline; PMC
abstract	Abstract The objectives were to determine the median infective dose (ID50) of Cryptosporidium parvum and to describe the dose–response relationship including associated clinical illness in experimentally challenged dairy calves. Within the first 24h of life, 27 test calves were experimentally challenged with C. parvum oocysts and 3 control calves were sham dosed. Test calves received 1 of 8 possible doses (25, 50, 100, 500, 1×103, 1×104, 1×105, and 1×106 oocysts). All 27 test calves developed diarrhea. Fecal oocyst shedding occurred in 25 (92.6%) test calves and in 0 control calves. The 2 non-shedding test calves both received 25 oocysts. There was an inverse relationship between dose and time to onset of fecal oocyst shedding (P =0.005). There was no relationship found between dose and duration (P =0.2) or cessation (P =0.3) of fecal oocyst shedding. In addition, there was not a significant relationship between log-dose and the log-peak oocysts (P =0.2) or log-total oocysts (P =0.5) counted/g of feces across the dose groups. There was a positive dose–response relationship between log-dose and diarrhea (P =0.01). However, when controlling for other factors, such as onset and cessation of fecal oocyst shedding, dose was not a significant predictor of diarrhea (P =0.5). Onset and cessation of fecal oocyst shedding were found to be the best predictors of diarrhea (P =0.0006 and P =0.04, respectively). The ID50 for fecal oocyst shedding was 5.8 oocysts, for diarrhea was 9.7 oocysts, and for fecal oocyst shedding with diarrhea was 16.6 oocysts. Given that the ID50 of C. parvum is far less than would be excreted into the environment by a naturally infected calf, prevention and control of cryptosporidiosis is a formidable challenge.
has issue date	2013-10-18(xsd:dateTime)
bibo:doi	10.1016/j.vetpar.2013.04.022
bibo:pmid	23680540
has license	els-covid
sha1sum (hex)	f5b25eb01c31fb75688dd8a11327d23b7cc0f421
schema:url	https://doi.org/10.1016/j.vetpar.2013.04.022
resource representing a document's title	Cryptosporidium parvum: Determination of ID50 and the dose–response relationship in experimentally challenged dairy calves
has PubMed Central identifier	PMC7116995
has PubMed identifier	23680540
schema:publication	Veterinary Parasitology
resource representing a document's body	covid:f5b25eb01c31fb75688dd8a11327d23b7cc0f421#body_text
is schema:about of	named entity 'factors' named entity 'There' named entity 'fecal' named entity 'oocyst' named entity 'However' named entity 'dose-response relationship' named entity 'life' named entity 'environment' named entity 'inverse relationship' named entity 'calves' named entity 'GIVEN' named entity '0.5' named entity 'ILLNESS' named entity 'OBJECTIVES' named entity 'FAR' named entity 'INCLUDING' named entity 'NON-' named entity 'FOUND' named entity 'INFECTIVE DOSE' named entity 'CALVES' named entity 'SHEDDING' covid:arg/f5b25eb01c31fb75688dd8a11327d23b7cc0f421 named entity '500' named entity 'TO DESCRIBE' named entity 'CRYPTOSPORIDIUM PARVUM' named entity 'FECAL' named entity 'SHAM' named entity 'CRYPTOSPORIDIOSIS' named entity 'CRYPTOSPORIDIUM PARVUM' named entity 'DOSE-RESPONSE RELATIONSHIP' named entity 'DETERMINATION' named entity 'DAIRY CALVES' named entity 'TOTAL' named entity 'CONTROLLING' named entity '50%' named entity 'ADDITION' named entity 'OOCYST' named entity '0.005' named entity 'ONSET' named entity 'GROUPS' named entity 'SIGNIFICANT' named entity 'BEST' named entity 'OOCYSTS' named entity 'ASSOCIATED' named entity 'DOSE' named entity 'LESS THAN' named entity 'ACROSS' named entity 'POSITIVE' named entity 'IS A' named entity '0.01' named entity 'RECEIVED' named entity 'WAS A' named entity 'CALF' named entity 'RELATIONSHIP' named entity 'TIME TO ONSET' named entity 'DURATION' named entity 'PREDICTOR' named entity '100%' named entity 'ENVIRONMENT' named entity 'SIGNIFICANT RELATIONSHIP' named entity 'DOSE-RESPONSE RELATIONSHIP' named entity 'LIFE' named entity '28P' named entity '0.2' named entity 'INVERSE' named entity 'PREVENTION AND CONTROL' named entity 'DIARRHEA' named entity 'DAIRY CALVES' named entity 'CLINICAL' named entity 'DETERMINE' named entity 'OCCURRED' named entity 'PEAK' named entity 'CESSATION' named entity 'CONTROL' named entity 'MEDIAN' named entity '0.04'

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