About: Chapter 4 Ligand-directed Cancer Gene Therapy to Angiogenic Vasculature

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chapter 4 Ligand-directed Cancer Gene Therapy to Angiogenic Vasculature
Creator	Arap, Wadih Pasqualini, Renata Driessen, Wouter Ozawa, Michael
Source	Elsevier; Medline; PMC
abstract	Abstract Gene therapy strategies in cancer have remained an active area of preclinical and clinical research. One of the current limitations to successful trials is the relative transduction efficiency to produce a therapeutic effect. While intratumoral injections are the mainstay of many treatment regimens to date, this approach is hindered by hydrostatic pressures within the tumor and is not always applicable to all tumor subtypes. Vascular-targeting strategies introduce an alternative method to deliver vectors with higher local concentrations and minimization of systemic toxicity. Moreover, therapeutic targeting of angiogenic vasculature often leads to enhanced bystander effects, improving efficacy. While identification of functional and systemically accessible molecular targets is challenging, approaches, such as in vivo phage display and phage-based viral delivery vectors, provide a platform upon which vascular targeting of vectors may become a viable and translational approach.
has issue date	2009-12-31(xsd:dateTime)
bibo:doi	10.1016/s0065-2660(09)67004-8
bibo:pmid	19914451
has license	els-covid
sha1sum (hex)	f53cfd54d5a928ae69d18e86d879757eb903cf1c
schema:url	https://doi.org/10.1016/s0065-2660%2809%2967004-8
resource representing a document's title	Chapter 4 Ligand-directed Cancer Gene Therapy to Angiogenic Vasculature
has PubMed Central identifier	PMC7172741
has PubMed identifier	19914451
schema:publication	Advances in Genetics
resource representing a document's body	covid:f53cfd54d5a928ae69d18e86d879757eb903cf1c#body_text
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