About: Interferon-Gamma Modulation of the Local T Cell Response to Alphavirus Encephalomyelitis

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About: Interferon-Gamma Modulation of the Local T Cell Response to Alphavirus Encephalomyelitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon-Gamma Modulation of the Local T Cell Response to Alphavirus Encephalomyelitis
Creator	Baxter, Victoria Griffin, Diane
Source	Medline; PMC
abstract	Infection of mice with Sindbis virus (SINV) provides a model for examining the role of the immune response to alphavirus infection of the central nervous system (CNS). Interferon-gamma (IFN-γ) is an important component of this response, and we show that SINV-infected differentiated neurons respond to IFN-γ in vitro by induction of antiviral genes and suppression of virus replication. To determine the in vivo effects of IFN-γ on SINV clearance and T cell responses, C57BL/6 mice lacking IFN-γ or IFN-γ receptor-1 were compared to wild-type (WT) mice after intracranial SINV infection. In WT mice, IFN-γ was first produced in the CNS by natural killer cells and then by CD4(+) and CD8(+) T cells. Mice with impaired IFN-γ signaling initiated clearance of viral RNA earlier than WT mice associated with CNS entry of more granzyme B-producing CD8(+) T cells. However, these mice established fewer CD8(+) tissue-resident memory T (T(RM)) cells and were more likely to experience reactivation of viral RNA synthesis late after infection. Therefore, IFN-γ suppresses the local development of granzyme B-expressing CD8(+) T cells and slows viral RNA clearance but promotes CD8(+) T(RM) cell establishment.
has issue date	2020-01-16(xsd:dateTime)
bibo:doi	10.3390/v12010113
bibo:pmid	31963302
has license	cc-by
sha1sum (hex)	f51b986600acc015fa48820a1ec11c90ea871d6d
schema:url	https://doi.org/10.3390/v12010113
resource representing a document's title	Interferon-Gamma Modulation of the Local T Cell Response to Alphavirus Encephalomyelitis
has PubMed Central identifier	PMC7019780
has PubMed identifier	31963302
schema:publication	Viruses
resource representing a document's body	covid:f51b986600acc015fa48820a1ec11c90ea871d6d#body_text
is schema:about of	named entity 'mice' named entity 'INFECTED' named entity 'IFN' named entity 'RESPOND TO' named entity 'IMMUNE RESPONSE' named entity 'DIFFERENTIATED' named entity 'PROVIDES' named entity 'INTERFERON-GAMMA' named entity 'T CELL RESPONSE' named entity 'RESPONSE TO' named entity 'INTERFERON-GAMMA' named entity 'ENCEPHALOMYELITIS' named entity 'ALPHAVIRUS' named entity 'LOCAL' named entity 'IMPORTANT' named entity 'VIRUS REPLICATION' named entity 'COMPONENT' named entity 'MODEL' named entity 'ALPHAVIRUS INFECTION' named entity 'ROLE' named entity 'SUPPRESSION' named entity 'NEURONS' named entity 'ANTIVIRAL' named entity 'EXAMINING' named entity 'SINDBIS VIRUS' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'RESPONSE' named entity 'IN VITRO' named entity 'MICE' named entity 'INFECTION' named entity 'INDUCTION' named entity 'RESPONSE TO' named entity 'MODULATION' named entity 'GENES' covid:arg/f51b986600acc015fa48820a1ec11c90ea871d6d named entity 'Interferon-gamma' named entity 'virus' named entity 'Modulation' named entity 'Encephalomyelitis' named entity 'mice' named entity 'central nervous' named entity 'SINV' named entity 'SINV' named entity 'SINV' named entity 'CD4 +' named entity 'infection' named entity 'encephalomyelitis' named entity 'RNA viruses' named entity 'granzyme' named entity 'infection' named entity 'neurons' named entity 'RNA' named entity 'granzyme' named entity 'NK cells' named entity 'SINV' named entity 'SINV' named entity 'alphavirus' named entity 'mouse strains' named entity 'CD8 +' named entity 'Permeabilization' named entity 'SINV' named entity 'multiple comparison' named entity 'NSV' named entity 'CD8 +' named entity 'Perforin' named entity 'mononuclear cells' named entity 'neurons' named entity 'Ifng' named entity 'viral RNA' named entity 'NK cells' named entity 'CD8 +' named entity 'β-actin' named entity 'granzyme' named entity 'alphavirus' named entity 'RNA-binding protein' named entity 'IFN-γ' named entity 'CD8 +' named entity 'cytokine' named entity 'CLNs' named entity 'alphavirus'

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