About: Virus-mediated autoimmunity in Multiple Sclerosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Virus-mediated autoimmunity in Multiple Sclerosis
Creator	Grigoriadis, Nikolaos Hadjigeorgiou, Georgios
source	Medline; PMC
abstract	Epidemiological data suggest the notion that in Multiple Sclerosis (MS) is an acquired autoimmune disease and the cause may be an environmental factor(s), probably infectious, in genetically susceptible individuals. Several cases of viral induced demyelinatimg encephalomyelitis in human beings and in experimental models as well as the presence of IgG oligoclonal bands in the cerebrospinal fluid indicate that the infectious factor may be viral. However, the absence of a specific virus identification in MS central nervous system may hardly support this notion. On the other hand, the partial response of patients with MS to immunosuppressive and immunomodulatory therapy support the evidence of an autoimmune etiology for MS. However, the autoimmune hypothesis shares the same criticism with the infectious one in that no autoantigen(s) specific to and causative for MS has ever been identified. Nevertheless, the absence of identifiable infectious agent, especially viral does not rule out its presence at a certain time – point and the concomitant long term triggering of an autoimmune cascade of events thereafter. Several concepts have emerged in an attempt to explain the autoimmune mechanisms and ongoing neurodegeneration in MS on the basis of the infectious – viral hypothesis.
has issue date	2006-02-19(xsd:dateTime)
bibo:doi	10.1186/1740-2557-3-1
bibo:pmid	16504001
has license	cc-by
sha1sum (hex)	f50b6632623eb4fe2193588b4f2c217c7125872d
schema:url	https://doi.org/10.1186/1740-2557-3-1
resource representing a document's title	Virus-mediated autoimmunity in Multiple Sclerosis
has PubMed Central identifier	PMC1397830
has PubMed identifier	16504001
schema:publication	J Autoimmune Dis
resource representing a document's body	covid:f50b6632623eb4fe2193588b4f2c217c7125872d#body_text
is schema:about of	named entity 'presence' named entity 'point' named entity 'concepts' named entity 'IgG' named entity 'specific' named entity 'CRITICISM' named entity 'NOTION' named entity 'MAY BE' named entity 'MEDIATED' named entity 'CASCADE' named entity 'HYPOTHESIS' named entity 'OLIGOCLONAL BANDS' named entity 'SHARES' named entity 'ONGOING' named entity 'ENCEPHALOMYELITIS' named entity 'MULTIPLE SCLEROSIS' named entity 'EPIDEMIOLOGICAL' named entity 'TIME' named entity 'AUTOANTIGEN' named entity 'IMMUNOMODULATORY THERAPY' named entity 'IMMUNOSUPPRESSIVE' named entity 'NEURODEGENERATION' named entity 'TRIGGERING' named entity 'AUTOIMMUNE' named entity 'VIRAL' named entity 'SUPPORT' named entity 'EVIDENCE OF' named entity 'ENVIRONMENTAL FACTOR' named entity '28S' named entity 'IGG' named entity 'MULTIPLE SCLEROSIS' named entity 'AUTOIMMUNE DISEASES' named entity 'MS.' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'CASES' named entity 'POINT' named entity 'ITS' named entity 'LONG TERM' named entity 'TO EXPLAIN' named entity 'CONCEPTS' named entity 'CONCOMITANT' named entity 'DOES NOT' named entity 'HUMAN' named entity 'VIRUS IDENTIFICATION' named entity 'DATA' named entity 'INFECTIOUS' named entity 'EXPERIMENTAL MODELS' named entity 'AUTOIMMUNE DISEASE' named entity 'SPECIFIC' named entity 'EVENTS' named entity 'PARTIAL RESPONSE' named entity 'CEREBROSPINAL FLUID' named entity 'ABSENCE OF' named entity 'HARDLY' named entity 'SUSCEPTIBLE' named entity 'ATTEMPT' named entity 'SUGGEST' named entity 'ETIOLOGY' named entity 'PATIENTS' named entity 'INDUCED' named entity 'HAVE' named entity 'FACTOR' named entity 'MECHANISMS' named entity 'PROBABLY' named entity 'IDENTIFIABLE' named entity 'CAUSE' named entity 'VIRUS' named entity 'HAND' named entity 'RULE OUT' named entity 'PRESENCE' named entity 'IDENTIFIED' named entity 'INDIVIDUALS' named entity 'CERTAIN' named entity 'AUTOIMMUNITY' named entity 'JOURNAL ' named entity 'ACQUIRED' named entity 'INFECTIOUS AGENT' named entity 'BASIS' named entity 'PRESENCE OF' covid:arg/f50b6632623eb4fe2193588b4f2c217c7125872d

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