About: Protective effects of hypericin against infectious bronchitis virus induced apoptosis and reactive oxygen species in chicken embryo kidney cells

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About: Protective effects of hypericin against infectious bronchitis virus induced apoptosis and reactive oxygen species in chicken embryo kidney cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protective effects of hypericin against infectious bronchitis virus induced apoptosis and reactive oxygen species in chicken embryo kidney cells
Creator	Ren, Yudong Wang, Xiurong Zhang, Yue Li, Guangxing Feng, Rui Abbas, Ghulam Chen, Huijie Diao, Lei Huang, Xiaodan Muhammad, Ishfaq Zhang, Ruili
topic	covid:f48acaa9b87ab31e2be26149983fd243c4a9be6f#this
Source	Elsevier; Medline; PMC
abstract	ABSTRACT Avian infectious bronchitis virus (IBV), a coronavirus, causes infectious bronchitis leading to enormous economic loss in the poultry industry worldwide. Hypericin (HY) is an excellent compound that has been investigated in antiviral, antineoplastic, and antidepressant. To investigate the inhibition effect of HY on IBV infection in chicken embryo kidney (CEK) cells, 3 different experimental designs: pre-treatment of cells prior to IBV infection, direct treatment of IBV-infected cells, and pre-treatment of IBV prior to cell infection were used. Quantitative real-time PCR (qRT-PCR), immunofluorescence assay (IFA), flow cytometry, and fluorescence microscopy were performed and virus titer was determined by TCID50. The results revealed that HY had a good anti-IBV effect when HY directly treated the IBV-infected cells, and virus infectivity decreased in a dose-dependent manner. Furthermore, HY inhibited IBV-induced apoptosis in CEK cells, and significantly reduced the mRNA expression levels of Fas, FasL, JNK, Bax, Caspase 3, and Caspase 8, and significantly increased Bcl-2 mRNA expression level in CEK cells. In addition, HY treatment could decrease IBV-induced reactive oxygen species (ROS) generation in CEK cells. These results suggested that HY showed potential antiviral activities against IBV infection involving the inhibition of apoptosis and ROS generation in CEK cells.
has issue date	2019-12-31(xsd:dateTime)
bibo:doi	10.3382/ps/pez465
bibo:pmid	31399732
has license	els-covid
sha1sum (hex)	f48acaa9b87ab31e2be26149983fd243c4a9be6f
schema:url	https://doi.org/10.3382/ps/pez465
resource representing a document's title	Protective effects of hypericin against infectious bronchitis virus induced apoptosis and reactive oxygen species in chicken embryo kidney cells
has PubMed Central identifier	PMC7107269
has PubMed identifier	31399732
schema:publication	Poultry Science
resource representing a document's body	covid:f48acaa9b87ab31e2be26149983fd243c4a9be6f#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/f48acaa9b87ab31e2be26149983fd243c4a9be6f
is schema:about of	named entity 'INDUCED' named entity 'poultry industry' named entity 'apoptosis' named entity 'activities' named entity 'coronavirus' named entity 'antiviral' named entity 'virus' named entity 'embryo' named entity 'reactive oxygen species' named entity 'APOPTOSIS' named entity 'DECREASE' named entity 'PCR' named entity 'USED' named entity 'EXCELLENT' named entity 'LEADING' named entity 'ECONOMIC LOSS' named entity 'VIRUS INFECTIVITY' named entity 'INVESTIGATED' named entity 'EFFECT' named entity 'DETERMINED BY' named entity 'INFECTION' named entity 'ANTINEOPLASTIC' named entity 'INCREASED' named entity 'EMBRYO' named entity 'CHICKEN' covid:arg/f48acaa9b87ab31e2be26149983fd243c4a9be6f named entity 'PERFORMED' named entity 'CEK' named entity 'APOPTOSIS' named entity 'REACTIVE OXYGEN SPECIES' named entity 'HYPERICIN' named entity 'EFFECTS' named entity 'KIDNEY' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'CELLS' named entity 'ADDITION' named entity 'TO INVESTIGATE' named entity 'GENERATION' named entity 'CAUSES' named entity 'EXPRESSION LEVEL' named entity 'EMBRYO' named entity 'CASPASE 8' named entity 'CHICKEN' named entity 'VIRUS' named entity 'ANTIDEPRESSANT' named entity 'COMPOUND' named entity 'EXPERIMENTAL DESIGNS' named entity 'DIRECT' named entity 'FLUORESCENCE MICROSCOPY' named entity 'DOSE-DEPENDENT' named entity 'FLOW CYTOMETRY' named entity 'TITER' named entity 'RESULTS' named entity 'CORONAVIRUS' named entity 'INFECTED' named entity 'FAS' named entity 'CELL' named entity 'FASL' named entity 'LEVELS' named entity 'POULTRY INDUSTRY' named entity 'TREATMENT' named entity 'WORLDWIDE' named entity 'BAX' named entity 'INFECTIOUS BRONCHITIS' named entity 'TREATED' named entity 'GOOD' named entity 'KIDNEY' named entity 'REAL-TIME PCR ' named entity 'IMMUNOFLUORESCENCE ASSAY'

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