About: CHARACTERIZATION OF ANTIBODIES INDUCED BY VACCINATION WITH HEPATITIS C VIRUS ENVELOPE GLYCOPROTEINS

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About: CHARACTERIZATION OF ANTIBODIES INDUCED BY VACCINATION WITH HEPATITIS C VIRUS ENVELOPE GLYCOPROTEINS Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CHARACTERIZATION OF ANTIBODIES INDUCED BY VACCINATION WITH HEPATITIS C VIRUS ENVELOPE GLYCOPROTEINS
Creator	Abrignani, Sergio Ray, Ranjit Basu, Arnab Houghton, Michael Belshe, Robert Banerjee, Arup Coates, Stephen Meyer, Keith Frey, Sharon
Source	Medline; PMC
abstract	Hepatitis C virus (HCV) envelope glycoproteins, E1 and E2, were used with MF59 adjuvant as a candidate vaccine for a phase I safety and immunogenicity trial. Ten of the 41 vaccinee sera tested displayed a VSV/HCV surrogate pseudotype neutralization titer of ≥1/20, 15 of the 36 sera tested had a neutralization titer of ≥ 1/400 against HIV/HCV pseudotype, and 10 of the 36 sera tested had a neutralization titer of ≥1/20 of cell culture grown HCVgenotype 1a. Neutralizing sera had increased affinity, and displayed >2 fold higher specific activity to well characterized epitopes on E1/E2, especially to the hypervariable region 1 (HVR1) of E2.
has issue date	2010-09-15(xsd:dateTime)
bibo:doi	10.1086/655902
bibo:pmid	20677942
has license	bronze-oa
sha1sum (hex)	f477facd4c2a04f94eec8e5ff858920034d37740
schema:url	https://doi.org/10.1086/655902
resource representing a document's title	CHARACTERIZATION OF ANTIBODIES INDUCED BY VACCINATION WITH HEPATITIS C VIRUS ENVELOPE GLYCOPROTEINS
has PubMed Central identifier	PMC2931414
has PubMed identifier	20677942
schema:publication	The Journal of Infectious Diseases
resource representing a document's body	covid:f477facd4c2a04f94eec8e5ff858920034d37740#body_text
is schema:about of	named entity 'titer' named entity 'Antibodies' named entity 'TITER' covid:arg/f477facd4c2a04f94eec8e5ff858920034d37740 named entity 'HCV' named entity 'ADJUVANT' named entity 'HCV GENOTYPE' named entity 'HIGHER' named entity 'PHASE 1' named entity 'TESTED' named entity 'EPITOPES' named entity 'TRIAL' named entity 'HEPATITIS C VIRUS' named entity 'VACCINATION' named entity 'FOLD' named entity 'CHARACTERIZATION' named entity 'INDUCED' named entity 'ANTIBODIES' named entity 'USED' named entity 'SERUM' named entity 'DISPLAYED' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'CHARACTERIZED' named entity 'GLYCOPROTEINS' named entity 'VIRUS ENVELOPE' named entity 'IMMUNOGENICITY' named entity 'SAFETY' named entity 'REGION 1' named entity 'LEVELS' named entity 'CELL CULTURE' named entity 'INCREASED AFFINITY' named entity 'SPECIFIC ACTIVITY' named entity 'CANDIDATE' named entity '831' named entity 'VACCINE' named entity 'VACCINEE' named entity 'HYPERVARIABLE REGION' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'MF59' named entity 'ACTIVITY LEVELS' named entity 'SAMPLES' named entity 'phase' named entity 'affinity' named entity 'Phe' named entity 'serum samples' named entity 'infectivity' named entity '2, 3' named entity 'VSV' named entity 'serum samples' named entity 'serum samples' named entity 'HCV' named entity 'phase 1' named entity 'Hepatitis C Virus' named entity 'Antibodies' named entity 'antibody' named entity 'avidity' named entity 'serum samples' named entity 'epitope' named entity 'serum samples' named entity 'real-time polymerase chain reaction' named entity 'HCV' named entity 'cell culture' named entity 'VSV' named entity 'epitope' named entity 'peroxidase' named entity 'avidin' named entity 'immune surveillance' named entity 'infection' named entity 'epitope' named entity 'positive control' named entity 'titer' named entity 'HVR1' named entity 'horseradish peroxidase'

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