About: The Relationship between Diabetes Mellitus and COVID-19 Prognosis: A Retrospective Cohort Study in Wuhan, China

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Relationship between Diabetes Mellitus and COVID-19 Prognosis: A Retrospective Cohort Study in Wuhan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Relationship between Diabetes Mellitus and COVID-19 Prognosis: A Retrospective Cohort Study in Wuhan, China
Creator	Wang, Qian Shang, Jian Zhang, Haiping Lin, Jun Cheng, Jie Yan, Youqin Wang, Xiaoyue Li, Ziang Gao, Yadong Wan, Jing
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease, first appeared in Wuhan, China, and quickly spread throughout the world. We aimed to understand the relationship between diabetes mellitus and the prognosis of COVID-19. METHODS: Demographic, clinical, laboratory, radiologic, treatments, complications, and clinical outcomes data were extracted from electronic medical records and compared between diabetes (n=84) and non-diabetes (n=500) groups. Kaplan-Meier method and multivariate Cox analysis were applied to determine the risk factors for the prognosis of COVID-19. RESULTS: Compared to non-diabetic patients, diabetic patients had higher levels of neutrophils (p = 0.014), c-reactive protein (p = 0.008), procalcitonin (p < 0.01), and D-dimer (p = 0.033), and lower levels of lymphocytes (p = 0.032) and albumin (p = 0.035). Furthermore, diabetic patients had a significant higher incidence of bilateral pneumonia (86.9%, p = 0.020). In terms of complications and clinical outcomes, the incidence of respiratory failure (36.9% vs. 24.2%, p = 0.022), acute cardiac injury (47.4% vs. 21.2%, p < 0.01) and death (20.2% vs. 8.0%, p = 0.001) in the diabetes group was significantly higher than that in non-diabetes group. Kaplan-Meier survival curve showed that COVID-19 patients with diabetes had a shorter overall survival time. Multivariate Cox analysis indicated that diabetes (HR 2.180, p = 0.031) was an independent risk factor for COVID-19 prognosis. In subgroup analysis, we divided diabetic patients into insulin required and non-insulin required groups according to whether they needed insulin, and found that diabetic patients requiring insulin may have a higher risk of disease progression and worse prognosis after the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). CONCLUSIONS: Diabetes is an independent risk factor for the prognosis of COVID-19. More attention should be paid to the prevention and treatment for diabetic patients, especially those who require insulin therapy.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.1016/j.amjmed.2020.05.033
bibo:pmid	32653423
has license	no-cc
sha1sum (hex)	f44e2750f49836369669f4aef979c93c47e61791
schema:url	https://doi.org/10.1016/j.amjmed.2020.05.033
resource representing a document's title	The Relationship between Diabetes Mellitus and COVID-19 Prognosis: A Retrospective Cohort Study in Wuhan, China
has PubMed Central identifier	PMC7350644
has PubMed identifier	32653423
schema:publication	Am J Med
resource representing a document's body	covid:f44e2750f49836369669f4aef979c93c47e61791#body_text
is schema:about of	named entity 'Wuhan' named entity 'prognosis' named entity 'China' named entity 'chronic liver' named entity 'log-rank test' named entity 'reference limit' named entity 'intravenous' named entity 'log-rank test' named entity 'Glycated hemoglobin' named entity 'insulin' named entity 'myocardial infarction' named entity 'South Korea' named entity 'clinical outcome' named entity 'confounding factors' named entity 'diabetes' named entity 'diabetes' named entity 'SARS' named entity 'inflammation' named entity 'antiviral treatment' named entity 'COVID-19' named entity 'pathogen' named entity 'insulin therapy' named entity 'diabetic patients' named entity 'lung' named entity 'diabetic patients' named entity 'chronic liver disease' named entity 'Wuhan Institute of Virology' named entity 'diabetes' named entity 'risk factor' named entity 'diabetic patients' named entity 'diabetic patients' named entity 'SARS-CoV-2' named entity 'lung' named entity 'transmission rate' named entity 'survival time' named entity 'troponin' named entity 'D-dimer' named entity 'diabetes' named entity 'diabetes' named entity 'multivariate analysis' named entity 'ACE2' named entity 'Kaplan-Meier' named entity 'symptom' named entity 'comorbidities' named entity 'COVID' named entity 'glucose tolerance test' named entity 'prognosis' named entity 'demographic' named entity 'demographic' named entity 'diabetic patients' named entity 'ACE2' named entity 'diabetic patients' named entity 'COVID-19' named entity 'elderly patients' named entity 'Diabetes mellitus' named entity 'interquartile range' named entity 'pathogen' named entity 'albumin' named entity 'elderly people' named entity 'demographic' named entity 'COVID-19' named entity 'MERS' named entity 'D-dimer' named entity 'diabetes mellitus' named entity 'adhesion molecules' named entity 'pulmonary embolism' named entity 'C-reactive protein' named entity 'prognosis' named entity 'kidney diseases' named entity 'inflammation' named entity 'liver' named entity 'liver'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software