About: The host targeting effect of chloroquine in malaria

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About: The host targeting effect of chloroquine in malaria Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The host targeting effect of chloroquine in malaria
Creator	Coban, Cevayir
topic	covid:f3f4bd38ce65cf17d90adfd0f6bb315628a52e8a#this
source	Elsevier; Medline; PMC
abstract	Due to the rapid onset and spread of the COVID-19 pandemic, the treatment of COVID-19 patients by hydroxychloroquine alone or in combination with other drugs has captured a great deal of attention and triggered considerable debate. Historically, the worldwide use of quinoline based-drugs has led to a spectacular reduction in death from malaria. Unfortunately, scientists have been forced to seek alternative drugs to treat malaria due to the emergence of chloroquine-resistant parasites in the 1960s. The repurposing of hydroxychloroquine against viral infections, various types of cancer and autoimmune diseases has been ongoing for more than 70 years, with no clear understanding of its mechanism of action (MOA). Here, we closely examine the MOA of this old but influential drug in and beyond malaria. Better insights into how chloroquine targets the host’s cellular and immune responses may help to develop applications against to new pathogens and diseases, and perhaps even restore the clinical utility of chloroquine against malaria.
has issue date	2020-08-18(xsd:dateTime)
bibo:doi	10.1016/j.coi.2020.07.005
bibo:pmid	32823144
has license	no-cc
sha1sum (hex)	f3f4bd38ce65cf17d90adfd0f6bb315628a52e8a
schema:url	https://doi.org/10.1016/j.coi.2020.07.005
resource representing a document's title	The host targeting effect of chloroquine in malaria
has PubMed Central identifier	PMC7431399
has PubMed identifier	32823144
schema:publication	Curr Opin Immunol
resource representing a document's body	covid:f3f4bd38ce65cf17d90adfd0f6bb315628a52e8a#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/f3f4bd38ce65cf17d90adfd0f6bb315628a52e8a
is schema:about of	named entity 'quinoline' named entity 'artemisinin' named entity 'The host' named entity 'chloroquine' named entity 'malaria' named entity 'resistance' named entity 'antibodies' named entity 'nutrient' named entity 'systemic lupus erythematosus' named entity 'parasites' named entity 'malaria infection' named entity 'blood stage' named entity 'primaquine' named entity 'hemozoin' named entity 'prophylactic' named entity 'hemozoin' named entity 'hydroxychloroquine' named entity 'quinoline' named entity 'chloroquine phosphate' named entity 'quinine' named entity 'chloroquine' named entity 'RBG' named entity 'Weak base' named entity 'ectodomain' named entity 'CD8 +' named entity 'amino acid' named entity 'Plasmodium' named entity 'mechanism of action' named entity 'heme' named entity 'SLE' named entity 'toxicity' named entity 'SLE' named entity 'life cycle' named entity 'chemoprophylaxis' named entity 'autophagy' named entity 'chloroquine' named entity 'genomic DNA' named entity 'chloroquine' named entity 'Ferriprotoporphyrin' named entity 'adaptor protein' named entity 'chloroquine' named entity 'nucleic acids' named entity 'parasite' named entity 'chloroquine' named entity 'hepatocytes' named entity 'weak base' named entity 'nucleus' named entity 'parasite' named entity 'vacuoles' named entity 'macrophages' named entity 'parasite resistance' named entity 'chloroquine' named entity 'erythrocytes' named entity 'autophagy' named entity 'erythrocytes' named entity 'weak base' named entity 'Chloroquine' named entity 'parasites' named entity 'host cells' named entity 'bafilomycin A1' named entity 'endosomes' named entity 'hemozoin' named entity 'adaptive immune' named entity 'hemozoin' named entity 'pleiotropic' named entity 'parasites' named entity 'autophagy' named entity 'Plasmodium falciparum' named entity 'hemozoin' named entity 'MOA' named entity 'chloroquine' named entity 'S. mansoni' named entity 'parasite' named entity 'placenta' named entity 'parasite' named entity 'liver' named entity 'endosomal' named entity 'hydroxychloroquine' named entity 'TLR'

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