About: Interferon Gene Expression in Sputum Cells Correlates with the Asthma Index Score During Virus-Induced Exacerbations

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon Gene Expression in Sputum Cells Correlates with the Asthma Index Score During Virus-Induced Exacerbations
Creator	Evans, J Mathur, Sameer Evans, M Gern, J Denlinger, L Gern, N Jarjour, N Jarjour, S Manthei, D Mathur, Mathur, S Schwantes, E
Source	PMC
abstract	RATIONALE: The majority of asthma exacerbations are related to viral respiratory infections. Some, but not all, previous studies have reported that low interferon responses in patients with asthma increase the risk for virus-induced exacerbations. OBJECTIVE: We sought to determine the relationship between lower airway inflammatory biomarkers, specifically interferon gene expression, and the severity or presence of an exacerbation in asthmatics experiencing a naturally occurring viral infection. METHODS: Sputum samples were analyzed from subjects in an asthma exacerbation study who experienced a confirmed viral infection. Subjects were monitored for daily symptoms, medication use, and peak expiratory flow rate until baseline. Sputum samples were assessed for cell counts and gene expression. RESULTS: IFN-γ expression was significantly greater in patients with asthma exacerbations compared to non-exacerbating patients (p=0.002). IFN-α1, IFN-β1, and IFN-γ mRNA levels correlated with the peak Asthma Index (r=0.58, p<0.001; r=0.57, p=0.001; and r=0.51, p=0.004, respectively). Additionally, IL-13, IL-10 and eosinophil major basic protein mRNA levels were greater in patients with asthma exacerbations compared to non-exacerbating patients (p=0.03, p=0.06, and p=0.02, respectively), and IL-13 mRNA correlated with the peak Asthma Index (p=0.006). CONCLUSIONS: Our findings indicate that asthma exacerbations are associated with increased rather than decreased expression of interferons early in the course of infection. These findings raise the possibility that excessive virus-induced interferon production during acute infections can contribute to airway inflammation and exacerbations of asthma.
has issue date	2014-05-24(xsd:dateTime)
bibo:doi	10.1111/cea.12269
bibo:pmid	24450586
has license	green-oa
sha1sum (hex)	f3ee67afa3aba69127b3d2aa261c7da12f38a803
schema:url	https://doi.org/10.1111/cea.12269
resource representing a document's title	Interferon Gene Expression in Sputum Cells Correlates with the Asthma Index Score During Virus-Induced Exacerbations
has PubMed Central identifier	PMC4037351
has PubMed identifier	24450586
schema:publication	Clinical & Experimental Allergy
resource representing a document's body	covid:f3ee67afa3aba69127b3d2aa261c7da12f38a803#body_text
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