About: Can Routine Laboratory Tests Discriminate between Severe Acute Respiratory Syndrome and Other Causes of Community-Acquired Pneumonia?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Can Routine Laboratory Tests Discriminate between Severe Acute Respiratory Syndrome and Other Causes of Community-Acquired Pneumonia?
Creator	Tang, Patrick Tomlinson, George Detsky, Allan Gold, Wayne Low, Donald Mcgeer, Allison Muller, Matthew Marrie, Thomas
topic	covid:f3ed733a3ab1038472d3cc38d221e8944f73279b#this
Source	Medline; PMC
abstract	Background. The clinical presentation of severe acute respiratory syndrome (SARS) resembles that of other etiologies of community-acquired pneumonia, making diagnosis difficult. Hematological and biochemical abnormalities, particularly lymphopenia, are common in patients with SARS. Methods. With the use of 2 databases, we compared the ability of the absolute lymphocyte count, absolute neutrophil count, lactate dehydrogenase level, creatine kinase level, alanine aminotransferase level, and serum calcium level at hospital admission to discriminate between cases of SARS and cases of community-acquired pneumonia. The SARS database contained data for 144 patients with SARS from the 2003 Toronto SARS outbreak. The community-acquired pneumonia database contained data for 8044 patients with community-acquired pneumonia from Edmonton, Canada. Patients from the SARS database were matched to patients from the community-acquired pneumonia database according to age, and receiver operating characteristic curves were constructed for each laboratory variable. Results. The areas under the receiver operating characteristic curves (AUCs) demonstrated fair to poor discriminatory ability for all laboratory variables tested except absolute neutrophil count, which had an AUC of 0.80, indicating good discriminatory ability (although there was no cutoff value of the absolute neutrophil count at which reasonable sensitivity or specificity could be obtained). Combinations of any 2 tests did not perform significantly better than did the absolute neutrophil count alone. Conclusions. Routine laboratory tests, including determination of absolute lymphocyte count, should not be used in the diagnosis of SARS or incorporated into current case definitions of SARS. The role of the absolute neutrophil count in SARS diagnosis is likely limited, but it should be assessed further.
has issue date	2005-04-15(xsd:dateTime)
bibo:doi	10.1086/428577
bibo:pmid	15791504
has license	no-cc
sha1sum (hex)	f3ed733a3ab1038472d3cc38d221e8944f73279b
schema:url	https://doi.org/10.1086/428577
resource representing a document's title	Can Routine Laboratory Tests Discriminate between Severe Acute Respiratory Syndrome and Other Causes of Community-Acquired Pneumonia?
has PubMed Central identifier	PMC7107805
has PubMed identifier	15791504
schema:publication	Clin Infect Dis
resource representing a document's body	covid:f3ed733a3ab1038472d3cc38d221e8944f73279b#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/f3ed733a3ab1038472d3cc38d221e8944f73279b
is schema:about of	named entity 'ROUTINE' named entity 'lymphopenia' named entity 'Hematological' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'DIFFICULT' named entity 'DIAGNOSIS' covid:arg/f3ed733a3ab1038472d3cc38d221e8944f73279b named entity 'LABORATORY TESTS' named entity 'CAUSES' named entity 'DISCRIMINATE' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'PATIENTS' named entity 'ABNORMALITIES' named entity 'LYMPHOPENIA' named entity 'COMMON' named entity 'ETIOLOGIES' named entity 'CLINICAL PRESENTATION' named entity 'HEMATOLOGICAL' named entity 'BIOCHEMICAL' named entity 'SARS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'presentation' named entity 'patients' named entity 'SARS' named entity 'Severe Acute Respiratory Syndrome' named entity 'Community-Acquired Pneumonia' named entity 'statistically significant' named entity '2.25' named entity 'China' named entity 'SARS' named entity 'epidemiological' named entity 'diagnostic accuracy' named entity 'severe acute respiratory syndrome' named entity 'seropositive' named entity 'seropositive' named entity 'auscultation' named entity 'SARS' named entity 'SARS' named entity 'aminotransferase' named entity 'severe acute respiratory syndrome' named entity 'Serological' named entity 'aminotransferase' named entity 'respiratory symptoms' named entity 'IgG antibodies' named entity 'CAP' named entity '1.1' named entity 'ANC' named entity 'CAP' named entity 'symptoms and signs' named entity 'clinical practice' named entity 'ANC' named entity 'clinical features' named entity 'SARS' named entity 'CAP' named entity 'SARS' named entity 'immunofluorescent' named entity 'SARS' named entity 'IgM' named entity 'symptoms and signs' named entity 'SARS' named entity 'sensitive and specific' named entity 'influenza' named entity 'SARS' named entity 'SARS' named entity 'SARS' named entity 'seropositive' named entity 'ALC' named entity 'SARS' named entity 'public health' named entity 'SARS' named entity 'SARS'

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