About: Genome-wide host responses against infectious laryngotracheitis virus vaccine infection in chicken embryo lung cells

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About: Genome-wide host responses against infectious laryngotracheitis virus vaccine infection in chicken embryo lung cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genome-wide host responses against infectious laryngotracheitis virus vaccine infection in chicken embryo lung cells
Creator	Kong, Byung-Whi Lee, Jeongyoon Bottje, Walter
Source	Medline; PMC
abstract	BACKGROUND: Infectious laryngotracheitis virus (ILTV; gallid herpesvirus 1) infection causes high mortality and huge economic losses in the poultry industry. To protect chickens against ILTV infection, chicken-embryo origin (CEO) and tissue-culture origin (TCO) vaccines have been used. However, the transmission of vaccine ILTV from vaccinated- to unvaccinated chickens can cause severe respiratory disease. Previously, host cell responses against virulent ILTV infections were determined by microarray analysis. In this study, a microarray analysis was performed to understand host-vaccine ILTV interactions at the host gene transcription level. RESULTS: The 44 K chicken oligo microarrays were used, and the results were compared to those found in virulent ILTV infection. Total RNAs extracted from vaccine ILTV infected chicken embryo lung cells at 1, 2, 3 and 4 days post infection (dpi), compared to 0 dpi, were subjected to microarray assay using the two color hybridization method. Data analysis using JMP Genomics 5.0 and the Ingenuity Pathway Analysis (IPA) program showed that 213 differentially expressed genes could be grouped into a number of functional categories including tissue development, cellular growth and proliferation, cellular movement, and inflammatory responses. Moreover, 10 possible gene networks were created by the IPA program to show intermolecular connections. Interestingly, of 213 differentially expressed genes, BMP2, C8orf79, F10, and NPY were expressed distinctly in vaccine ILTV infection when compared to virulent ILTV infection. CONCLUSIONS: Comprehensive knowledge of gene expression and biological functionalities of host factors during vaccine ILTV infection can provide insight into host cellular defense mechanisms compared to those of virulent ILTV.
has issue date	2012-04-24(xsd:dateTime)
bibo:doi	10.1186/1471-2164-13-143
bibo:pmid	22530940
has license	cc-by
sha1sum (hex)	f3e85a35ab89c9a55eeb83c6e17f881d5c497d82
schema:url	https://doi.org/10.1186/1471-2164-13-143
resource representing a document's title	Genome-wide host responses against infectious laryngotracheitis virus vaccine infection in chicken embryo lung cells
has PubMed Central identifier	PMC3353197
has PubMed identifier	22530940
schema:publication	BMC Genomics
resource representing a document's body	covid:f3e85a35ab89c9a55eeb83c6e17f881d5c497d82#body_text
is schema:about of	named entity 'RESPONSES' named entity 'transcription' named entity 'NPY' named entity 'poultry industry' named entity 'hybridization' named entity 'expressed' named entity 'vaccine' named entity 'INFECTIOUS LARYNGOTRACHEITIS VIRUS' named entity 'PATHWAY ANALYSIS' named entity 'COLOR' named entity 'SEVERE' named entity 'CONNECTIONS' named entity 'EMBRYO' named entity 'DAYS' named entity 'COMPARED' named entity 'HOST CELL' named entity 'RESULTS' named entity 'INFLAMMATORY RESPONSES' named entity 'GROUPED' named entity 'C8ORF79' named entity 'HUGE' named entity 'VACCINATED' named entity 'RNAS' named entity 'GENOMICS' named entity 'TOTAL' named entity 'HOST' named entity 'ECONOMIC' named entity 'USING' named entity 'NUMBER OF' named entity 'LUNG' named entity 'TISSUE' named entity 'UNDERSTAND' named entity 'CHICKENS' named entity 'GENE TRANSCRIPTION' named entity 'DPI' named entity 'RESPONSES' named entity 'WIDE' named entity 'CHICKEN' named entity 'VIRUS VACCINE' named entity 'CELLS' named entity 'GENOME' named entity 'GALLID HERPESVIRUS 1' named entity 'CAUSES' named entity 'EMBRYO' named entity 'MICROARRAY ANALYSIS' named entity 'POULTRY INDUSTRY' named entity 'INFECTIOUS LARYNGOTRACHEITIS VIRUS' named entity 'EXPRESSED' named entity 'STUDY' named entity 'INCLUDING' named entity 'VIRULENT' named entity 'TRANSMISSION' named entity 'DETERMINED BY' named entity 'FOUND' named entity 'MORTALITY' named entity 'CELLULAR GROWTH AND PROLIFERATION' named entity 'TISSUE DEVELOPMENT' named entity 'GENE NETWORKS' named entity 'HYBRIDIZATION' named entity 'POSSIBLE' named entity 'NPY' named entity 'PREVIOUSLY' named entity 'LUNG' named entity 'POST' named entity 'VACCINE' named entity 'CREATED BY' named entity 'MICROARRAY ASSAY' named entity 'PROGRAM' named entity 'BACKGROUND' named entity 'PERFORMED' named entity 'IPA' named entity 'EXTRACTED' named entity 'METHOD' named entity 'INTERACTIONS' named entity 'CELLULAR' named entity 'ORIGIN' named entity 'HAVE' named entity 'MOVEMENT' named entity 'HIGH'

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