About: Prevalence of respiratory viruses and antiviral MxA responses in children with febrile urinary tract infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prevalence of respiratory viruses and antiviral MxA responses in children with febrile urinary tract infection
Creator	Waris, Matti Peltola, Ville Toivonen, Laura Ivaska, Lauri Lempainen, Johanna Yahya, Mohamed Kataja, Janne Nuolivirta, Kirsi Piri, Ruut Tripathi, Lav
Source	Medline; PMC
abstract	Blood myxovirus resistance protein A (MxA) has broad antiviral activity, and it is a potential biomarker for symptomatic virus infections. Limited data is available of MxA in coinciding viral and bacterial infections. We investigated blood MxA levels in children hospitalized with a febrile urinary tract infection (UTI) with or without simultaneous respiratory virus infection. We conducted a prospective observational study of 43 children hospitalized with febrile UTI. Nasopharyngeal swab samples were collected at admission and tested for 16 respiratory viruses by nucleic acid detection methods. Respiratory symptoms were recorded, and blood MxA levels were determined. The median age of study children was 4 months (interquartile range, 2–14 months). A respiratory virus was detected in 17 (40%) children with febrile UTI. Of the virus-positive children with febrile UTI, 7 (41%) had simultaneous respiratory symptoms. Blood MxA levels were higher in virus-positive children with respiratory symptoms (median, 778 [interquartile range, 535–2538] μg/L) compared to either virus-negative (155 [94–301] μg/L, P < 0.001) or virus-positive (171 [112–331] μg/L, P = 0.006) children without respiratory symptoms at presentation with febrile UTI. MxA differentiated virus-positive children with respiratory symptoms from virus-negative without symptoms by an area under the receiver operating characteristic curve of 0.96. Respiratory viruses were frequently detected in children with febrile UTI. In UTI with simultaneous respiratory symptoms, host antiviral immune response was demonstrated by elevated blood MxA protein levels. MxA protein could be a robust biomarker of symptomatic viral infection in children with febrile UTI.
has issue date	2020-02-11(xsd:dateTime)
bibo:doi	10.1007/s10096-020-03836-5
bibo:pmid	32048070
has license	cc-by
sha1sum (hex)	f3c5fc978814031d5d832b7aac9a75de041e4597
schema:url	https://doi.org/10.1007/s10096-020-03836-5
resource representing a document's title	Prevalence of respiratory viruses and antiviral MxA responses in children with febrile urinary tract infection
has PubMed Central identifier	PMC7088029
has PubMed identifier	32048070
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:f3c5fc978814031d5d832b7aac9a75de041e4597#body_text
is schema:about of	named entity 'robust' named entity 'UTI' named entity 'prospective' named entity 'febrile' named entity 'febrile' named entity 'HIGHER' named entity '2538' named entity 'SAMPLES' named entity 'ANTIVIRAL ACTIVITY' named entity 'ROBUST' named entity 'RANGE' named entity 'PROTEIN LEVELS' named entity 'NUCLEIC ACID DETECTION' named entity 'hospitalized' named entity 'immune response' named entity 'detection' named entity 'levels' named entity 'febrile' named entity 'UTI' named entity 'acid' named entity 'virus' named entity 'virus' named entity 'antiviral' named entity 'conducted' named entity 'interquartile range' named entity 'UTI' named entity 'Respiratory' named entity 'simultaneous' named entity 'respiratory' named entity 'demonstrated' named entity 'symptoms' named entity 'symptoms' named entity 'simultaneous' named entity 'respiratory' named entity 'MxA' named entity 'UTI' named entity 'urinary tract infection' named entity 'UTI' named entity 'UTI' named entity 'MxA' named entity 'respiratory symptoms' named entity 'UTI' named entity 'UTI' named entity 'respiratory symptoms' named entity 'respiratory symptoms' named entity 'median age' named entity 'virus' named entity 'febrile' named entity 'MxA' named entity 'urinary tract infection' named entity 'antiviral' named entity 'protein' named entity 'respiratory symptoms' named entity 'protein' named entity 'coinfected' named entity 'PCR' named entity 'RTI' named entity 'urine samples' named entity 'MxA' named entity 'Creative Commons Attribution 4.0' named entity 'Urine samples' named entity 'urine' named entity 'Boxtel' named entity 'virus infection' named entity 'WBC' named entity 'OC43' named entity 'bacterial growth' named entity 'virus' named entity 'UTI' named entity 'rotavirus vaccination' named entity 'febrile' named entity 'plasma'

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