About: Mechanical ventilation with heliox in an animal model of acute respiratory distress syndrome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mechanical ventilation with heliox in an animal model of acute respiratory distress syndrome
Creator	Juffermans, Nicole Aslami, Hamid Beurskens, Charlotte De Beer, Friso Roelofs, Joris Vroom, Margreeth
Source	PMC
abstract	BACKGROUND: Heliox has a lower density and higher diffusion capacity compared to oxygen-in-air. We hypothesized that heliox ventilation allows for a reduction in minute volume ventilation and inspiratory pressures needed for adequate gas exchange in an animal model of an acute lung injury. METHODS: After intratracheal instillation of lipopolysaccharide (10 mg/kg), adult rats were randomized to ventilation with either a gas mixture of helium/oxygen (50:50%) or oxygen/air (50:50%). They were mechanically ventilated according to the ARDSnet recommendations with tidal volumes of 6 ml/kg and monitored with a pneumotachometer. Bronchoalveolar lavage fluid was analyzed for markers of lung injury, and embedded lung sections were histologically scored for lung injury. RESULTS: Heliox limited the increase in driving pressures needed to achieve preset tidal volumes, with a concomitant decrease in loss of compliance. Heliox did neither allow for reduced minute volume ventilation in this model nor improve gas exchange. Also, heliox did not reduce lung injury. CONCLUSIONS: Heliox modestly improved respiratory mechanics but did not improve lung injury in this rat model of acute respiratory distress syndrome.
has issue date	2014-02-06(xsd:dateTime)
bibo:doi	10.1186/2197-425x-2-8
bibo:pmid	26266912
has license	cc-by
sha1sum (hex)	f3a75a57d895e69896c77e7a887e26211501c816
schema:url	https://doi.org/10.1186/2197-425x-2-8
resource representing a document's title	Mechanical ventilation with heliox in an animal model of acute respiratory distress syndrome
has PubMed Central identifier	PMC4513042
has PubMed identifier	26266912
schema:publication	Intensive Care Med Exp
resource representing a document's body	covid:f3a75a57d895e69896c77e7a887e26211501c816#body_text
is schema:about of	named entity 'ventilation' named entity 'ADULT' named entity 'HELIUM' named entity 'COMPARED' named entity 'histologically' named entity 'adult' named entity 'Bronchoalveolar lavage' named entity 'pressures' named entity 'density' named entity 'They' named entity 'randomized' named entity 'compared' named entity 'tidal' named entity 'acute lung injury' named entity 'helium' named entity 'intratracheal instillation' named entity 'mechanically ventilated' named entity 'heliox' named entity 'Bronchoalveolar lavage fluid' named entity 'lung injury' named entity 'lower density' named entity 'animal model' named entity 'animal model' named entity 'Mechanical ventilation' named entity 'acute respiratory distress syndrome' named entity 'pediatric' named entity 'gas mixture' named entity 'Lung' named entity 'animal model' named entity 'Hugstetten' named entity 'lung inflammation' named entity 'gas exchange' named entity 'lung' named entity 'lung' named entity 'Siemens' named entity 'diffusion' named entity 'Germany' named entity 'Hugstetten' named entity 'CINC' named entity 'animal models' named entity 'ARDS' named entity 'intraperitoneal injection' named entity 'tidal volume' named entity 'heliox' named entity 'respiratory rate' named entity 'COPD' named entity 'inflammatory response' named entity 'asthma' named entity 'cannula' named entity 'catheter' named entity 'Heliox' named entity 'respiration' named entity 'Germany' named entity 'heliox' named entity 'gas exchange' named entity 'heliox' named entity 'leukocytes' named entity 'rectally' named entity 'heliox' named entity 'technical gas' named entity '2.0' named entity 'laminar flow' named entity 'Espoo' named entity 'Netherlands' named entity 'heliox' named entity 'invasive ventilation' named entity 'anesthesia' named entity 'heliox' named entity 'ARDS' named entity 'oxygen' named entity 'heliox' named entity 'Tidal' named entity 'gas mixture' named entity 'inflammation' named entity 'lung' named entity 'lung'

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