About: The causes of false-positives encountered during the screening of old-world primates for antibodies to human and simian retroviruses by ELISA

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About: The causes of false-positives encountered during the screening of old-world primates for antibodies to human and simian retroviruses by ELISA Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The causes of false-positives encountered during the screening of old-world primates for antibodies to human and simian retroviruses by ELISA
Creator	Marx, Preston Baulu', Jean Gardner7, Murray Higgins4, Joanne Lowenstine', Linda Mcguire6, Michael Pedersen', Niels
Source	Elsevier; Medline; PMC
abstract	Abstract Sera from 526 old-world primates representing 50 different species were screened by ELISA for antibodies to human T-lymphotropic viruses I and III, and simian retrovirus type 1 (SRV-1). About onefourth of the sera were positive by ELISA. There was a tendency, however, for the same sera to be positive for all three human and simian retroviruses. Only about one in five of the ELISA antibodypositive sera were confirmed to be positive by Western blotting. False-positive ELISA antibody tests were particularly common among sera from mandrills, crab-eating macaques, lion-tailed macaques, African green monkeys, and DeBrazza's and moustached guenons. Sera that were falsely positive in ELISA antibody tests to the three human and simian retroviruses were found to contain antibodies that reacted at comparable intensity with feline leukemia, infectious peritonitis and panleukopenia viruses. The false anti-viral activity of these sera was found to be due to antibodies that reacted with non-viral proteins that were copurified with all five virus preparations. These proteins were present in normal cat and human cells used to grow the various viruses and in gelatin. The implications of nonspecific cell-protein antibodies in primate sera were discussed in the light of this and previous seroepidemiologic studies of man and old-world monkeys.
has issue date	1986-11-30(xsd:dateTime)
bibo:doi	10.1016/0166-0934(86)90023-6
bibo:pmid	3025237
has license	els-covid
sha1sum (hex)	f3987d12f5def1ab7819155b3670d3e0782effd9
schema:url	https://doi.org/10.1016/0166-0934%2886%2990023-6
resource representing a document's title	The causes of false-positives encountered during the screening of old-world primates for antibodies to human and simian retroviruses by ELISA
has PubMed Central identifier	PMC7119498
has PubMed identifier	3025237
schema:publication	Journal of Virological Methods
resource representing a document's body	covid:f3987d12f5def1ab7819155b3670d3e0782effd9#body_text
is schema:about of	named entity 'SIMIAN' named entity 'FALSE' named entity 'antibodies' named entity 'WORLD' named entity 'CAUSES' named entity 'SCREENING' named entity 'POSITIVES' named entity 'HUMAN' named entity 'ELISA' named entity 'RETROVIRUSES' named entity 'ANTIBODIES' named entity 'OLD' named entity 'PRIMATES' named entity 'primates' named entity 'false-positives' named entity 'old-world' named entity 'sera' named entity 'African green monkey' named entity 'antibody' named entity 'viral protein' named entity 'protein' named entity 'FIPV' named entity 'HTLV-III' named entity 'antibody' named entity 'talapoin' named entity 'cell lysates' named entity 'antigens' named entity 'liver' named entity 'incubation' named entity 'false-positive' named entity 'HTLV-III' named entity 'Complement fixation tests' named entity 'FeLV' named entity 'FeLV' named entity 'FeLV' named entity 'FeLV' named entity 'lion-tailed macaques' named entity 'HTLV-III' named entity 'antibodies' named entity 'false positive' named entity 'Antibody' named entity 'Laemmli' named entity 'virus' named entity 'FeLV' named entity 'old-world' named entity 'gelatin' named entity 'antibody' named entity 'antibody' named entity 'African green monkey' named entity 'Pasteur Institute' named entity 'antibodies' named entity 'IgG' named entity 'Human T-lymphotropic virus' named entity 'virus' named entity 'antibodies' named entity 'HTLV-III' named entity 'antigen' named entity 'antibody' named entity 'pygmy chimpanzees' named entity 'Plasmodium falciparum' named entity 'antigen' named entity 'Antibodies' named entity 'Marx' named entity 'core protein' named entity 'antibody' named entity 'simian retrovirus' named entity 'HTLV-I' named entity 'virus' named entity 'polyacrylamide' named entity 'antibody' named entity 'antibodies' named entity 'antibody' named entity 'mandrills' named entity 'optical density' named entity 'HTLV-I'

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