About: Glycoprotein gene truncation in avian metapneumovirus subtype C isolates from the United States

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About: Glycoprotein gene truncation in avian metapneumovirus subtype C isolates from the United States Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Glycoprotein gene truncation in avian metapneumovirus subtype C isolates from the United States
Creator	Velayudhan, Binu Ae, Yu Estevez, Carlos Halvorson, David Kakambi, A Nagaraja, V Qingzhong, A
Source	PMC
abstract	The length of the published glycoprotein (G) gene sequences of avian metapneumovirus subtype-C (aMPV-C) isolated from domestic turkeys and wild birds in the United States (1996–2003) remains controversial. To explore the G gene size variation in aMPV-C by the year of isolation and cell culture passage levels, we examined 21 turkey isolates of aMPV-C at different cell culture passages. The early domestic turkey isolates of aMPV-C (aMPV/CO/1996, aMPV/MN/1a-b, and 2a-b/97) had a G gene of 1,798 nucleotides (nt) that coded for a predicted protein of 585 amino acids (aa) and showed >97% nt similarity with that of aMPV-C isolated from Canada geese. This large G gene got truncated upon serial passages in Vero cell cultures by deletion of 1,015 nt near the end of the open reading frame. The recent domestic turkey isolates of aMPV-C lacked the large G gene but instead had a small G gene of 783 nt, irrespective of cell culture passage levels. In some cultures, both large and small genes were detected, indicating the existence of a mixed population of the virus. Apparently, serial passage of aMPV-C in cell cultures and natural passage in turkeys in the field led to truncation of the G gene, which may be a mechanism of virus evolution for survival in a new host or environment.
has issue date	2008-07-29(xsd:dateTime)
bibo:doi	10.1007/s11262-008-0220-6
bibo:pmid	18663568
has license	no-cc
sha1sum (hex)	f37dbb70774918e09347840faf41f54262399417
schema:url	https://doi.org/10.1007/s11262-008-0220-6
resource representing a document's title	Glycoprotein gene truncation in avian metapneumovirus subtype C isolates from the United States
has PubMed Central identifier	PMC2516547
has PubMed identifier	18663568
schema:publication	Virus Genes
resource representing a document's body	covid:f37dbb70774918e09347840faf41f54262399417#body_text
is schema:about of	named entity 'indicating' named entity 'gene' named entity 'detected' named entity 'isolates' named entity 'cell cultures' named entity 'large' named entity 'turkey' named entity 'NEAR' named entity 'AVIAN METAPNEUMOVIRUS' named entity 'REMAINS' named entity 'CULTURES' named entity 'BUT' named entity 'DOMESTIC' named entity 'IN THE FIELD' named entity 'DELETION' named entity 'TURKEYS' named entity 'passages' named entity 'similarity' named entity 'United States' named entity 'cell culture' named entity 'existence' named entity 'Canada geese' named entity 'nucleotides' named entity 'gene' named entity 'glycoprotein' named entity 'gene sequences' named entity 'open reading frame' named entity 'Vero cell' named entity 'gene' named entity 'cell cultures' named entity 'domestic turkey' named entity 'protein' named entity 'domestic turkey' named entity 'turkeys' named entity 'gene' named entity 'virus' named entity 'domestic turkey' named entity 'selective pressure' named entity 'turkey' named entity 'August 1999' named entity 'PBS' named entity 'conjunctivitis' named entity 'glycoprotein' named entity 'serum' named entity 'gene' named entity 'glycoprotein' named entity 'glycoprotein' named entity 'Qiagen' named entity 'cell culture' named entity 'glycoprotein' named entity 'vaccine strain' named entity 'Canada goose' named entity 'glycoprotein' named entity 'supernatant' named entity 'gene' named entity 'gene' named entity 'cell culture' named entity 'gene sequencing' named entity 'turkeys' named entity 'genome' named entity 'glycoprotein' named entity 'pathogen' named entity 'glycoprotein' named entity 'turkeys' named entity 'gene' named entity 'viruses' named entity 'penicillin G sodium' named entity 'glycoprotein' named entity 'gene' named entity 'RT-PCR' named entity 'cloning vector' named entity 'Vero' named entity 'Vero' named entity 'Minnesota' named entity 'cell attachment'

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