About: Epimedium-derived phytoestrogen exert beneficial effect on preventing steroid-associated osteonecrosis in rabbits with inhibition of both thrombosis and lipid-deposition

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About: Epimedium-derived phytoestrogen exert beneficial effect on preventing steroid-associated osteonecrosis in rabbits with inhibition of both thrombosis and lipid-deposition Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epimedium-derived phytoestrogen exert beneficial effect on preventing steroid-associated osteonecrosis in rabbits with inhibition of both thrombosis and lipid-deposition
Creator	Chan, C Zhang, G Lee, K Leung, K Cheung, W Griffith, J Qin, L Sheng, H Yeung, H Yeung, K
Source	Elsevier; PMC
abstract	OBJECTIVES: This study tested the effect of Epimedium-derived phytoestrogen (PE) on preventing steroid-associated osteonecrosis (ON) in rabbit model. METHODS: Thirty 28-week-old male New-Zealand white rabbits were divided into control group (CON; n = 14) and PE group (PE; n = 16; 5 mg/kg body weight/day) after receiving an established inductive protocol for inducing steroid-associated ON. Before and after inductive protocol, Dynamic-MRI was employed on bilateral femora for local intra-osseous perfusion, blood samples were examined for coagulation, fibrinolysis and lipid-transportation, and marrow samples were quantified for adipogenesis-gene mRNA expression. Six weeks later, bilateral femora were dissected for Micro-CT-based micro-angiography, and then ON lesion, intravascular thrombosis and extravascular fat-cell-size were examined histopathologically. RESULTS: The incidence of ON in the PE group (31%) was significantly lower than that in the CON group (93%). Compared to the CON group, local intra-osseous perfusion was maintained in the PE group. Blocked trunk vessels were seldom found in micro-angiography of the PE-treated rabbits. Thrombosis incidence and fat-cell-size were both significantly lower in the PE group than those in the CON group. During the early period after induction, indicator of coagulation, fibrinolysis, lipid-transportation and adipogenesis-gene expression were found with significantly changing pattern in the PE group compared to the CON group. CONCLUSION: PE was able to exert beneficial effect on preventing steroid-associated ON in rabbits with inhibition of both thrombosis and lipid deposition.
has issue date	2006-12-22(xsd:dateTime)
bibo:doi	10.1016/j.bone.2006.10.026
has license	no-cc
sha1sum (hex)	f368b5f2c55688705788f1184b7720173f26974a
schema:url	https://doi.org/10.1016/j.bone.2006.10.026
resource representing a document's title	Epimedium-derived phytoestrogen exert beneficial effect on preventing steroid-associated osteonecrosis in rabbits with inhibition of both thrombosis and lipid-deposition
has PubMed Central identifier	PMC7185875
schema:publication	Bone
resource representing a document's body	covid:f368b5f2c55688705788f1184b7720173f26974a#body_text
is schema:about of	named entity 'thrombosis' named entity 'employed' named entity 'rabbits' named entity 'coagulation' named entity 'VESSELS' named entity 'DISSECTED' named entity 'FIBRINOLYSIS' named entity 'THROMBOSIS' named entity 'OLD' named entity 'ZEALAND' named entity 'LIPID' named entity 'PHYTOESTROGEN' named entity 'day' named entity 'mRNA' named entity 'histopathologically' named entity 'CON' named entity 'osteonecrosis' named entity 'indicator' named entity 'receiving' named entity 'Thirty' named entity 'perfusion' named entity 'inducing' named entity 'gene' named entity 'intravascular' named entity 'blood samples' named entity 'thrombosis' named entity 'angiography' named entity 'Thrombosis' named entity 'Micro-CT' named entity 'angiography' named entity 'fat' named entity 'lipid' named entity 'fat' named entity 'thrombosis' named entity 'histopathologically' named entity 'lipid' named entity 'phytoestrogen' named entity 'quantified' named entity 'deposition' named entity 'distal' named entity 'lipid' named entity 'Epimedium' named entity 'endothelium' named entity 'significant difference' named entity 'fat cells' named entity 'Animal Experiment' named entity 'Reverse transcription polymerase chain reaction' named entity 'North China' named entity 'osteoporosis' named entity 'MRI' named entity 'organ' named entity 'extravascular' named entity 'steroid' named entity 'lipid' named entity 'fibrinolysis' named entity 'histology' named entity 'LPS' named entity 'Daidzein' named entity 'coagulation' named entity 'field of view' named entity 'ANCOVA' named entity 'angiographic' named entity 'distal' named entity 'Icariin' named entity 'Sigma-Aldrich' named entity 'lower limb' named entity 'proximal femur' named entity 'LPS' named entity 'thrombosis' named entity 'lipid' named entity 'lipid-lowering agent' named entity 'Intravascular' named entity 'long-term' named entity 'LPS'

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