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  • Abstract Hematological changes in patients with Severe Acute Respiratory Syndrome (SARS) are common and frequently include thrombocytopenia. Using a ELISA method, we found an increase in thrombopoietin (TPO) levels in the plasma of convalesced SARS patients (290±53 pg/ml) and active SARS patients (251±23 pg/ml) comparing to that from normal control patients (228±17 pg/ml). In addition, the plasma from active SARS patients had an inhibitory effect on CFU-MK formation, which could be neutralized by anti-TGF-β antibodies. In the experiment to determine whether SARS-CoV can directly infect hematopoietic stem cells and megakaryocytic cells, incubation of the cells with SARS-CoV did not show active infection. Our findings of increased TPO levels in the plasma of SARS patients provide a possible explanation for the genesis of thrombocytosis, which frequently develops from thrombocytopenia in SARS patients.
Subject
  • Severe acute respiratory syndrome
  • Hematology
  • Viral respiratory tract infections
  • Leukocytes
  • Bird diseases
  • Syndromes affecting the respiratory system
  • Zoonotic bacterial diseases
  • Atypical pneumonias
  • Bat virome
  • Sarbecovirus
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