About: Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence

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About: Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
Creator	Drosten, Christian Grenfell, Bryan Wang, Lin-Fa Chandran, Kartik Boots, Mike Ng, Melinda Brook, Cara Dobson, Andrew Graham, Andrea Haydon, Dan Mü Ller, Marcel Van Leeuwen, Anieke
Source	Medline; PMC
abstract	Bats host virulent zoonotic viruses without experiencing disease. A mechanistic understanding of the impact of bats’ virus hosting capacities, including uniquely constitutive immune pathways, on cellular-scale viral dynamics is needed to elucidate zoonotic emergence. We carried out virus infectivity assays on bat cell lines expressing induced and constitutive immune phenotypes, then developed a theoretical model of our in vitro system, which we fit to empirical data. Best fit models recapitulated expected immune phenotypes for representative cell lines, supporting robust antiviral defenses in bat cells that correlated with higher estimates for within-host viral propagation rates. In general, heightened immune responses limit pathogen-induced cellular morbidity, which can facilitate the establishment of rapidly-propagating persistent infections within-host. Rapidly-transmitting viruses that have evolved with bat immune systems will likely cause enhanced virulence following emergence into secondary hosts with immune systems that diverge from those unique to bats.
has issue date	2020-02-03(xsd:dateTime)
bibo:doi	10.7554/elife.48401
bibo:pmid	32011232
has license	cc-by
sha1sum (hex)	f2cc0d63ff2c4aaa127c4caae21d8f3a0067e3d5
schema:url	https://doi.org/10.7554/elife.48401
resource representing a document's title	Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
has PubMed Central identifier	PMC7064339
has PubMed identifier	32011232
schema:publication	eLife
resource representing a document's body	covid:f2cc0d63ff2c4aaa127c4caae21d8f3a0067e3d5#body_text
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