About: Response of rat tracheal epithelium to ozone and oxygen exposure in vitro

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Response of rat tracheal epithelium to ozone and oxygen exposure in vitro
Creator	Nikula, Kristen Wilson, Anddennis
Source	Elsevier; Medline; PMC
abstract	Abstract Although ozone-induced epithelial injury in vivo has been morphologically characterized, effects of gaseous oxidants on respiratory epithelium in organ culture, where tissue organization is maintained but systemic influences are eliminated, have not been thoroughly investigated. In this study, we exposed tracheal organ cultures from rats to 95% oxygen and 1 ppm ozone, alone and in combination, to determine (1) whether epithelial responses to ozone similar to those observed in vivo occur in airways separated from systemic physiologic, secretory, and inflammatory reactions; (2) whether concentrations of oxygen sufficient to potentially cause oxidant injury result in morphologic epithelial alterations similar to those that occur in ozone toxicity; and (3) if the combined oxidant insult of oxygen and ozone results in more severe damage to the tracheal epithelium than occurs with ozone in air. Tracheal organ cultures were exposed to filtered air and 5% carbon dioxide; filtered air, 5% carbon dioxide, and 1 ppm ozone; 95% oxygen and 5% carbon dioxide; or 95% oxygen, 5% carbon dioxide, and 1 ppm ozone for 96 hr. Light- and quantitative electron-microscopic evaluation showed that epithelia to 1 ppm ozone in air exhibited loss of ciliated cells and ciliated cell damage. The epithelia exposed to 95% oxygen and 5% carbon dioxide were pseudostratified, columnar, ciliated, and hyperplastic. Epithelia exposed to 95% oxygen plus 1 ppm ozone were stratified and nonciliated or very sparsely ciliated. The predominant cell types in epithelia exposed to oxygen plus ozone were serous cells and metaplastic cells, and focal aggregates of adherent necrotic cells were present. We conclude that there was a synergism between oxygen and ozone exposure leading to enhanced epithelial injury and metaplasia.
has issue date	1990-07-31(xsd:dateTime)
bibo:doi	10.1016/0272-0590(90)90169-k
bibo:pmid	2373293
has license	els-covid
sha1sum (hex)	f2b8aacf202904d7881c95d0823c76cc359fbff8
schema:url	https://doi.org/10.1016/0272-0590%2890%2990169-k
resource representing a document's title	Response of rat tracheal epithelium to ozone and oxygen exposure in vitro
has PubMed Central identifier	PMC7131117
has PubMed identifier	2373293
schema:publication	Fundamental and Applied Toxicology
resource representing a document's body	covid:f2b8aacf202904d7881c95d0823c76cc359fbff8#body_text
is schema:about of	named entity 'RAT' named entity 'OXYGEN EXPOSURE' named entity 'IN VITRO' named entity 'OBSERVED' named entity 'TRACHEAL' named entity 'DETERMINE' named entity 'RESPONSES' named entity 'BUT' named entity 'AIRWAYS' named entity 'GASEOUS' named entity 'IN VIVO' named entity 'OZONE' named entity 'RESPONSE' named entity 'COMBINATION' named entity 'INDUCED' named entity 'TRACHEAL EPITHELIUM' named entity 'THOROUGHLY' named entity 'HAVE' named entity 'EPITHELIAL' named entity 'ELIMINATED' named entity 'SIMILAR' named entity 'ORGAN CULTURE' named entity 'OCCUR' named entity 'EFFECTS' named entity 'TISSUE' named entity 'RATS' named entity 'PHYSIOLOGIC' named entity 'WHERE' named entity 'APPL' named entity 'ORGANIZATION' named entity 'INFLAMMATORY REACTIONS' named entity 'CHARACTERIZED' named entity 'MAINTAINED' named entity 'STUDY' named entity 'SECRETORY' named entity 'ORGAN CULTURES' named entity 'EXPOSED' named entity 'OXIDANTS' named entity 'OXYGEN' named entity 'RESPIRATORY EPITHELIUM' named entity 'OZONE' named entity 'INVESTIGATED' named entity 'PPM' named entity 'SYSTEMIC' named entity 'SEPARATED FROM' named entity 'INJURY' covid:arg/f2b8aacf202904d7881c95d0823c76cc359fbff8 named entity 'oxidants' named entity 'organ culture' named entity 'epithelial' named entity 'ozone' named entity 'respiratory epithelium' named entity 'epithelial' named entity 'inflammatory reactions' named entity 'Oxygen' named entity 'mitotic figures' named entity 'ozone' named entity 'ciliated' named entity 'columnar or cuboidal' named entity 'ciliated cell' named entity 'epithelial' named entity 'basal cells' named entity 'ozone' named entity 'tonofilaments' named entity 'epithelial' named entity 'VAX' named entity 'oxidant' named entity 'arc discharge' named entity 'basement membrane' named entity 'ciliated' named entity 'ciliated cell' named entity 'endoplasmic reticulum' named entity 'Intermediate cells' named entity 'carbon dioxide' named entity 'oxygen' named entity 'oxidants' named entity 'epithelium' named entity 'oxidant' named entity 'metaplasia' named entity 'epithelium'

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