About: Excess deaths in people with cardiovascular diseases during the COVID-19 pandemic.

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Excess deaths in people with cardiovascular diseases during the COVID-19 pandemic.
Creator	Hu, Yu Pillay, Deenan Lai, Alvina Shah, Ajay Tang, Williams, Bryan Wong, Wai Banerjee, Amitava Denaxas, Spiros Guo, Yutao Hemingway, Harry Katsoulis, Michail Khunti, Kamlesh Liang, V Lip, Gregory Noursadeghi, Mahdad Pareek, Nilesh Pasea, Laura Sudlow, Cathie Teo, James Bakhai, Ameet Bromage, Daniel Byrne, Jonathan Chen, Suliang Humberstone, Ben Mcdonagh, Theresa Nafilyan, Vahe Rubboli, Andrea Shah, Anoop Wu, Honghan
Source	MedRxiv
abstract	Background: Cardiovascular diseases(CVD) increase mortality risk from coronavirus infection(COVID-19), but there are concerns that the pandemic has affected supply and demand of acute cardiovascular care. We estimated excess mortality in specific CVDs, both direct, through infection, and indirect, through changes in healthcare. Methods: We used population-based electronic health records from 3,862,012 individuals in England to estimate pre- and post-COVID-19 mortality risk(direct effect) for people with incident and prevalent CVD. We incorporated: (i)pre-COVID-19 risk by age, sex and comorbidities, (ii)estimated population COVID-19 prevalence, and (iii)estimated relative impact of COVID-19 on mortality(relative risk, RR: 1.5, 2.0 and 3.0). For indirect effects, we analysed weekly mortality and emergency department data for England/Wales and monthly hospital data from England(n=2), China(n=5) and Italy(n=1) for CVD referral, diagnosis and treatment until 1 May 2020. Findings: CVD service activity decreased by 60-100% compared with pre-pandemic levels in eight hospitals across China, Italy and England during the pandemic. In China, activity remained below pre-COVID-19 levels for 2-3 months even after easing lockdown, and is still reduced in Italy and England. Mortality data suggest indirect effects on CVD will be delayed rather than contemporaneous(peak RR 1.4). For total CVD(incident and prevalent), at 10% population COVID-19 rate, we estimated direct impact of 31,205 and 62,410 excess deaths in England at RR 1.5 and 2.0 respectively, and indirect effect of 49932 to 99865 excess deaths. Interpretation: Supply and demand for CVD services have dramatically reduced across countries with potential for substantial, but avoidable, excess mortality during and after the COVID-19 pandemic.
has issue date	2020-06-11(xsd:dateTime)
bibo:doi	10.1101/2020.06.10.20127175
has license	medrxiv
sha1sum (hex)	f22d654d94c461ffd15f46bf1d827f6cd0362bdf
schema:url	https://doi.org/10.1101/2020.06.10.20127175
resource representing a document's title	Excess deaths in people with cardiovascular diseases during the COVID-19 pandemic.
resource representing a document's body	covid:f22d654d94c461ffd15f46bf1d827f6cd0362bdf#body_text
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