About: A Schiff Base-Derived Copper (II) Complex Is a Potent Inducer of Apoptosis in Colon Cancer Cells by Activating the Intrinsic Pathway

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About: A Schiff Base-Derived Copper (II) Complex Is a Potent Inducer of Apoptosis in Colon Cancer Cells by Activating the Intrinsic Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Schiff Base-Derived Copper (II) Complex Is a Potent Inducer of Apoptosis in Colon Cancer Cells by Activating the Intrinsic Pathway
Creator	Hassandarvish, Pouya Hajrezaie, Maryam Karimian, Hamed Paydar, Mohammadjavad Rouhollahi, Elham Zahedifard, Maryam Abdulla, Mahmood Ali, Hapipah Gwaram, Nura Looi, Chung Majid, Nazia Moghadamtousi, Soheil
Source	PMC
abstract	Metal-based drugs with extensive clinical applications hold great promise for the development of cancer chemotherapeutic agents. In the last few decades, Schiff bases and their complexes have become well known for their extensive biological potential. In the present study, we examined the antiproliferative effect of a copper (II) complex on HT-29 colon cancer cells. The Cu(BrHAP)(2 ) Schiff base compound demonstrated a potent antiproliferative effect in HT-29 cells, with an IC(50 )value of 2.87 μg/ml after 72 h of treatment. HT-29 cells treated with Cu (II) complexes underwent apoptosis death, as exhibited by a progressive elevation in the proportion of the G(1 ) cell population. At a concentration of 6.25 μg/ml, the Cu(BrHAP)(2 ) compound caused significant elevation in ROS production following perturbation of mitochondrial membrane potential and cytochrome c release, as assessed by the measurement of fluorescence intensity in stained cells. Furthermore, the activation of caspases 3/7 and 9 was part of the Cu (II) complex-induced apoptosis, which confirmed the involvement of mitochondrial-mediated apoptosis. Meanwhile, there was no significant activation of caspase-8. Taken together, these results imply that the Cu(BrHAP)(2 ) compound is a potential candidate for further in vivo and clinical colon cancer studies to develop novel chemotherapeutic agents derived from metal-based agents.
has issue date	2014-03-05(xsd:dateTime)
bibo:doi	10.1155/2014/540463
bibo:pmid	24737979
has license	cc-by
sha1sum (hex)	f1f24521928f5d8565a15a17bd7f79239a3d4116
schema:url	https://doi.org/10.1155/2014/540463
resource representing a document's title	A Schiff Base-Derived Copper (II) Complex Is a Potent Inducer of Apoptosis in Colon Cancer Cells by Activating the Intrinsic Pathway
has PubMed Central identifier	PMC3967396
has PubMed identifier	24737979
schema:publication	ScientificWorldJournal
resource representing a document's body	covid:f1f24521928f5d8565a15a17bd7f79239a3d4116#body_text
is schema:about of	named entity 'CAUSED' named entity 'RESULTS' named entity 'PART OF' named entity 'DERIVED' named entity 'VALUE' named entity 'COMPLEXES' named entity 'COPPER' named entity 'CELLS' named entity 'ACTIVATION' named entity 'BIOLOGICAL' named entity 'COMPOUND' named entity 'IS A' named entity 'SCHIFF BASE' named entity 'DERIVED' named entity 'develop' named entity 'complex' named entity 'elevation' named entity 'HT-29' named entity 'vivo' named entity 'cancer' named entity 'Inducer' named entity 'IS A' named entity 'COMPLEX' covid:arg/f1f24521928f5d8565a15a17bd7f79239a3d4116 named entity 'CONCENTRATION OF' named entity 'CONFIRMED' named entity 'FOLLOWING' named entity 'GREAT' named entity 'HOLD' named entity 'CANCER CELLS' named entity 'PROGRESSIVE' named entity 'POTENTIAL' named entity 'CASPASES' named entity 'CASPASE-8' named entity 'CYTOCHROME C' named entity 'MITOCHONDRIAL MEMBRANE POTENTIAL' named entity 'APOPTOSIS' named entity 'CHEMOTHERAPEUTIC AGENTS' named entity 'RELEASE' named entity 'TREATED WITH' named entity 'SCHIFF BASE' named entity 'INTRINSIC PATHWAY' named entity 'COLON CANCER' named entity 'CANCER CELLS' named entity 'ACTIVATING' named entity 'PERTURBATION' named entity 'TAKEN' named entity 'HT-29' named entity 'ANTIPROLIFERATIVE' named entity 'BASED' named entity 'COMPLEX' named entity '6.25' named entity 'EXAMINED' named entity 'NOVEL' named entity 'MITOCHONDRIAL' named entity 'DEATH' named entity 'KNOWN' named entity 'ROS' named entity 'IN VIVO' named entity 'PROPORTION' named entity 'ASSESSED' named entity 'STAINED' named entity 'THESE' named entity 'MEASUREMENT' named entity 'COPPER' named entity 'INDUCER OF APOPTOSIS' named entity 'THEIR' named entity 'PROMISE' named entity 'DRUGS' named entity 'STUDIES'

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