About: Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide
Creator	Zhang, Yi Wang, Li Wang, Liying Wan, Min Yu, Yongli Chen, Jianzhu Wang, Junzhi Wu, Xiuli Bao, Musheng Dai, Li Deng, Ping Hu, Xiaoping Liu, Yongjun
source	Elsevier; Medline; PMC
abstract	To develop CpG oligodeoxynucleotides (CpG ODNs) based therapy for prevention and treatment of severe acute respiratory syndrome (SARS), we selected a novel CpG ODN (BW001), which displays B-type CpG ODN structure feature at the 5′ and A-type CpG ODN structure feature at the 3′, and tested for its anti-SARS-CoV activity. We found that the supernatants of human PBMCs stimulated by BW001 significantly protected Vero cells from SARS-CoV infection. BW001 could stimulate human PBMCs and pDCs to secrete high level of IFN-α and promote human PBMCs and B cells to proliferate. Furthermore, we demonstrated that BW001 could activate CD19(+) B cells and CD56(+) NK cells in human PBMCs. In addition, BW001 could enhance NK cytotoxicity and IFN-γ secretion in human PBMCs. Together, BW001 represents a novel type of CpG ODN and may have potential for the development of treatment and prevention for SARS as well as other viral associated diseases.
has issue date	2005-11-17(xsd:dateTime)
bibo:doi	10.1016/j.clim.2005.09.014
bibo:pmid	16298165
has license	no-cc
sha1sum (hex)	f1d5d3319029102a40e081a3240c092badbb7411
schema:url	https://doi.org/10.1016/j.clim.2005.09.014
resource representing a document's title	Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide
has PubMed Central identifier	PMC7110578
has PubMed identifier	16298165
schema:publication	Clin Immunol
resource representing a document's body	covid:f1d5d3319029102a40e081a3240c092badbb7411#body_text
is schema:about of	covid:arg/f1d5d3319029102a40e081a3240c092badbb7411 named entity 'IFN-g' named entity 'NK cells' named entity 'SARS' named entity 'severe acute respiratory syndrome' named entity 'secretion' named entity 'cytotoxicity' named entity 'RNA' named entity 'China' named entity 'VSV' named entity 'EDTA' named entity 'IFN-a' named entity 'Cape Cod' named entity 'SARS' named entity 'CD14' named entity 'CpG' named entity 'secretion' named entity 'Shanghai' named entity 'anti-viral' named entity 'SARS' named entity 'etiologically' named entity 'chemokines' named entity 'SARS-CoV' named entity 'CD14' named entity 'tgt' named entity 'IFN-a' named entity 'VSV' named entity 'A-type' named entity 'CpG ODN' named entity 'IFN-a' named entity 'Vero E6' named entity 'PBMCs' named entity 'up-regulate' named entity 'CpG ODN' named entity 'SARS-CoV' named entity 'PBMCs' named entity 'EDTA' named entity 'PBMCs' named entity 'anti-viral' named entity 'CpG' named entity 'cough' named entity 'Vero E6' named entity 'PBMCs' named entity 'IFN-a' named entity 'CpG ODN' named entity 'viral replication' named entity 'CpG ODN' named entity 'penicillin' named entity 'antibiotics' named entity 'CpG' named entity 'HCV' named entity 'TE buffer' named entity 'Microtiter Plate' named entity 'vaccines' named entity 'CD56' named entity 'CpG' named entity 'Beijing' named entity 'IFN-a' named entity 'serum' named entity 'pDCs' named entity 'respiratory syncytial virus (RSV) infection' named entity 'pDCs' named entity 'monocytes' named entity 'excretion' named entity 'anti-viral' named entity 'counts per minute' named entity 'mice' named entity 'cytokine' named entity 'PBMCs'

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