About: Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study
Creator	Wang, Qi Tan, Li Wang, Qiongshu Ding, Jinya Huang, Qianchuan Miao, Hongming Tang, Yi-Quan Zhang, Duanyang
Source	MedRxiv
abstract	Background: Coronavirus disease-2019 (COVID-19) is a rapidly escalating epidemic caused by SARS-CoV-2. Identification of a simple and effective indicator to assess disease severity and outcome is urgently needed. Methods: This study retrospectively analyzed dynamic changes of lymphocyte percentage (LYM%) in 15 death cases, 15 severe cases as well as 40 moderate cases of COVID-19 patients. Next, prognostic role of lymphopenia in COVID-19 were verified in 92 hospitalized cases. Results: Our results from death and severe cases showed that LYM% in blood test were inversely associated with the progression and severity of COVID-19. LYM% in patients with moderate COVID-19 remained higher than 20% 10-12 days after symptom onset. In contrast, LYM% was lower than 20% in severe cases. However, LYM% in severe cases was higher than 5% 17-19 days after the onset of the disease, while it fell below 5% in death cases. Therefore, we established a reliable Time from symptom onset-LYM% model (TLM), which could be used to evaluate disease severity and predict the outcomes of hospitalized patients with COVID-19. Conclusion: Lymphopenia can be used to indicate clinical course, treatment effect and outcomes of COVID-19 patients.
has issue date	2020-03-03(xsd:dateTime)
bibo:doi	10.1101/2020.03.01.20029074
has license	medrxiv
sha1sum (hex)	f19e2df932f90f387fe71533f3802875d9042160
schema:url	https://doi.org/10.1101/2020.03.01.20029074
resource representing a document's title	Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study
resource representing a document's body	covid:f19e2df932f90f387fe71533f3802875d9042160#body_text
is schema:about of	named entity 'Lymphopenia' named entity 'CORONAVIRUS DISEASE' named entity 'COVID-19' named entity 'CAUSED BY' named entity 'ASSESS' named entity 'NEEDED' named entity 'IDENTIFICATION' named entity 'DISEASE SEVERITY' named entity 'PREDICTIVE' named entity 'BACKGROUND' named entity 'RAPIDLY' named entity 'PROGNOSIS' named entity 'DISEASE SEVERITY' named entity 'DESCRIPTIVE' named entity 'SUMMARY' named entity 'IS A' named entity 'EFFECTIVE' named entity 'SIMPLE' named entity 'INDICATOR' named entity 'STUDY' named entity 'LYMPHOPENIA' named entity 'EPIDEMIC' named entity '2019' named entity 'SARS-COV-2' covid:arg/f19e2df932f90f387fe71533f3802875d9042160 named entity 'assess' named entity 'prognosis' named entity 'simple' named entity 'disease' named entity 'COVID' named entity 'Coronavirus disease' named entity 'SARS-CoV-2' named entity 'prognosis' named entity 'organ failure' named entity 'preprint' named entity 'preprint' named entity 'lymphocyte' named entity 'coronavirus' named entity 'moderate cases' named entity 'fever' named entity 'pathogen' named entity 'inflammatory response' named entity 'medRxiv' named entity 'preprint' named entity 'lymphocyte' named entity 'biochemical' named entity 'biochemical' named entity 'sputum' named entity 'lymphocyte' named entity 'COVID' named entity 'lactate dehydrogenase' named entity 'medRxiv' named entity 'COVID' named entity 'critically ill' named entity 'COVID' named entity 'sample size' named entity 'cytokine storm' named entity 'China' named entity 'COVID' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'Wuhan' named entity 'preprint' named entity 'coronavirus infection' named entity 'lymphocyte' named entity 'coagulation' named entity 'medRxiv' named entity 'lymphocytes' named entity 'respiratory infections' named entity 'preprint' named entity 'prognosis' named entity 'prognosis' named entity 'prognosis' named entity 'pro-inflammatory cytokines' named entity 'preprint' named entity 'COVID' named entity 'epidemic' named entity 'lymphocyte' named entity 'CC-BY-NC-ND 4.0'

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