About: Anti-Inflammatory and Anti-Allergic Activities of Pentaherb Formula, Moutan Cortex (Danpi) and Gallic Acid

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About: Anti-Inflammatory and Anti-Allergic Activities of Pentaherb Formula, Moutan Cortex (Danpi) and Gallic Acid Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti-Inflammatory and Anti-Allergic Activities of Pentaherb Formula, Moutan Cortex (Danpi) and Gallic Acid
Creator	Hu, Shuiqing Hon, Kam Lam, Christopher Leung, Ping Wong, Chun Chan, Ben Fung, Kwok Hui, Patrick Lau, Clara Liu, Kelly Wat, Elaine
Source	Medline; PMC
abstract	Pentaherb formula (PHF) has been proven to improve the quality of life of children with atopic dermatitis without side effects. The aim of this study was to elucidate the potential anti-inflammatory and anti-allergic activities of PHF, Moutan Cortex (Danpi/DP) and gallic acid (GA) using human basophils (KU812 cells), which are crucial effector cells in allergic inflammation. PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p < 0.05). With the combined use of dexamethasone (0.01 μg/mL) and GA (10 μg/mL), the suppression of ICAM-1 expression and CCL5 and IL-6 release of IL-33-activated KU812 cells were significantly greater than the use of GA alone (all p < 0.05). The suppression of the IL-33-induced activation of intracellular signalling molecules p38 mitogen activated protein kinase, nuclear factor-κB and c-Jun amino-terminal kinase in GA-treated KU812 cells could be the underlying mechanism for the suppression on ICAM-1, chemokines and cytokines. The combined use of dexamethasone with the natural products PHF or DP or GA might therefore enhance the development of a novel therapeutic modality for allergic inflammatory diseases with high potency and fewer side effects.
has issue date	2013-02-25(xsd:dateTime)
bibo:doi	10.3390/molecules18032483
bibo:pmid	23439564
has license	cc-by
sha1sum (hex)	f14e7b5fff3c2ac074e61beacf4fb1bba524e438
schema:url	https://doi.org/10.3390/molecules18032483
resource representing a document's title	Anti-Inflammatory and Anti-Allergic Activities of Pentaherb Formula, Moutan Cortex (Danpi) and Gallic Acid
has PubMed Central identifier	PMC6270292
has PubMed identifier	23439564
schema:publication	Molecules
resource representing a document's body	covid:f14e7b5fff3c2ac074e61beacf4fb1bba524e438#body_text
is schema:about of	named entity 'GALLIC ACID' named entity 'MOUTAN CORTEX' named entity 'ANTI-INFLAMMATORY' named entity 'ANTI-INFLAMMATORY' named entity 'DEXAMETHASONE' named entity 'ALLERGIC' named entity 'MOLECULES' named entity 'ALLERGIC' named entity 'SUPPRESS' named entity 'UPREGULATED' named entity 'COMBINED' named entity 'IL-6' named entity 'CHEMOKINES CCL2' named entity 'SIDE EFFECTS' named entity 'ACTIVITIES' named entity 'USE OF' named entity 'CHILDREN' named entity 'FORMULA' named entity 'ALLERGIC INFLAMMATION' named entity 'KU812' named entity 'EXPRESSION' named entity 'INTERCELLULAR ADHESION MOLECULE' named entity 'STUDY' named entity 'AIM' named entity 'CCL5' named entity 'PHF' named entity 'CYTOKINE ' named entity 'IL-33' named entity 'QUALITY OF LIFE' named entity 'ACTIVITIES' named entity '0.05' named entity 'FORMULA' named entity 'ATOPIC DERMATITIS' named entity 'HUMAN' named entity 'BCG' named entity 'ICAM-1' named entity 'BASOPHILS' named entity 'INFLAMMATORY CYTOKINE' named entity 'POTENTIAL' named entity 'GALLIC ACID' named entity 'CELLS' named entity 'USING' named entity 'CXCL8' named entity 'PROVEN' named entity 'MOUTAN CORTEX' named entity 'EFFECTOR' named entity 'RELEASE' named entity 'SUPPRESSION' covid:arg/f14e7b5fff3c2ac074e61beacf4fb1bba524e438 named entity 'anti-allergic' named entity 'allergic' named entity 'atopic dermatitis' named entity 'upregulated' named entity 'Moutan' named entity 'Gallic Acid' named entity 'corticosteroids' named entity 'GA10' named entity 'IκBα' named entity 'Moutan' named entity 'IκBα' named entity 'cytokines' named entity 'IL-33' named entity 'CXCL8' named entity 'nude mice' named entity 'allergy' named entity 'phosphorylated' named entity 'GA10' named entity 'TCM' named entity 'p38 MAPK' named entity 'Fullerton, CA' named entity 'CXCL8'

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