About: Engineering the PRRS virus genome: Updates and perspectives

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Engineering the PRRS virus genome: Updates and perspectives
Creator	Han, Mingyuan Yoo, Dongwan
Source	Elsevier; Medline; PMC
abstract	Porcine reproductive and respiratory syndrome virus (PRRSV) is endemic in most pig producing countries worldwide and causes enormous economic losses to the pork industry. Infectious clones for PRRSV have been constructed, and so far at least 14 different infectious clones are available representing both genotypes I and II. Two strategies have been taken for progeny reconstitution: RNA transfection and DNA transfection. Mutations, insertions, deletions, and replacements of the viral genome have been employed to study the structure function relationship, foreign gene expression, functional complementation, and virulence determinants. Essential regions and non-essential regions for viral replication have been identified in both the coding regions and non-encoding regions. Foreign sequences have successfully been inserted into the nsp2 and N regions and in the space between ORF1b and ORF2a. Chimeras between member viruses in the family Arteriviridae have also been constructed and utilized to study cell tropism and functional complementation. This review discusses the advances and utilization of PRRSV reverse genetics and its potential for future research.
has issue date	2014-12-05(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2014.10.007
bibo:pmid	25458419
has license	no-cc
sha1sum (hex)	f148b5f765624a782d972dd3a1da01ac7e6c2831
schema:url	https://doi.org/10.1016/j.vetmic.2014.10.007
resource representing a document's title	Engineering the PRRS virus genome: Updates and perspectives
has PubMed Central identifier	PMC7172560
has PubMed identifier	25458419
schema:publication	Vet Microbiol
resource representing a document's body	covid:f148b5f765624a782d972dd3a1da01ac7e6c2831#body_text
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