About: Longitudinal analysis of the antibody repertoire of a Zika virus-infected patient revealed dynamic changes in antibody response

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About: Longitudinal analysis of the antibody repertoire of a Zika virus-infected patient revealed dynamic changes in antibody response Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Longitudinal analysis of the antibody repertoire of a Zika virus-infected patient revealed dynamic changes in antibody response
Creator	Chen, Ling Zhang, Fan Wang, Qian Zhang, Fuchun Zhao, Lingzhai Wang, Chunlin Liu, Tingting Feng, Liqiang Lei, Hui Li, Pingchao Liang, Renshan Luo, Jia Niu, Xuefeng Qu, Linbing Yan, Qihong Yao, Zhipeng Wu, Hongkai Han, Jian Chen, Chaoming Luo, Kun Wang, Chengrui Wang, Longyu Zhang, Yudi Zhang, Zhenhai Zheng, Zhiqiang Tan, Yee
Source	Medline; PMC
abstract	The Zika virus (ZIKV) is a mosquito-borne flavivirus that causes neonatal abnormalities and other disorders. Antibodies to the ZIKV envelope (E) protein can block infection. In this study, next-generation sequencing (NGS) of immunoglobulin heavy chain (IgH) mRNA transcripts was combined with single-cell PCR cloning of E-binding monoclonal antibodies for analysing antibody response in a patient from the early stages of infection to more than one year after the clearance of the virus. The patient's IgH repertoire 14 and 64 days after symptom onset showed dramatic dominant clonal expansion but low clonal diversity. IgH repertoire 6 months after disease-free status had few dominant clones but increased diversity. E-binding antibodies appeared abundantly in the repertoire during the early stages of infection but quickly declined after clearance of the virus. Certain VH genes such as VH5-10-1 and VH4-39 appeared to be preferentially enlisted for a rapid antibody response to ZIKV infection. Most of these antibodies require relatively few somatic hypermutations to acquire the ability to bind to the E protein, pointing to a possible mechanism for rapid defence against ZIKV infection. This study provides a unique and holistic view of the dynamic changes and characteristics of the antibody response to ZIKV infection.
has issue date	2020-01-06(xsd:dateTime)
bibo:doi	10.1080/22221751.2019.1701953
bibo:pmid	31906823
has license	cc-by
sha1sum (hex)	f0f89b444071b6fa4be64b86e5d70a4cab8cb492
schema:url	https://doi.org/10.1080/22221751.2019.1701953
resource representing a document's title	Longitudinal analysis of the antibody repertoire of a Zika virus-infected patient revealed dynamic changes in antibody response
has PubMed Central identifier	PMC6968589
has PubMed identifier	31906823
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:f0f89b444071b6fa4be64b86e5d70a4cab8cb492#body_text
is schema:about of	named entity 'INFECTED' named entity 'infection' named entity 'early stages' named entity 'flavivirus' named entity 'clearance' named entity 'clearance' named entity 'single-cell' named entity 'analysing' named entity 'TRANSCRIPTS' named entity 'ABNORMALITIES' named entity 'IS A' named entity 'CHANGES' named entity 'EARLY STAGES' named entity 'UNIQUE' named entity 'ANTIBODY RESPONSE' named entity 'GENES' named entity 'MOST OF' named entity 'MOSQUITO' named entity 'DISEASE-FREE' named entity 'ENVELOPE' named entity 'ANTIBODIES' named entity 'SOMATIC' named entity 'MORE THAN ONE' named entity 'MRNA' named entity 'RAPID' named entity 'IMMUNOGLOBULIN HEAVY CHAIN' named entity 'VH5' named entity 'BLOCK' named entity 'POINTING' named entity 'ONE YEAR' named entity 'ANTIBODY REPERTOIRE' named entity 'ZIKA VIRUS' named entity 'ANTIBODY RESPONSE' named entity 'DYNAMIC' named entity 'PATIENT' named entity 'VIRUS' named entity 'BINDING' named entity 'FLAVIVIRUS' named entity 'MECHANISM' named entity 'ZIKA VIRUS' named entity 'RESPONSE TO' named entity 'DAYS' named entity 'CLONES' named entity 'IGH' named entity 'INFECTION' named entity 'PATIENT' named entity 'DOMINANT' named entity 'SYMPTOM ONSET' named entity 'CLONING' named entity 'MONTHS' named entity 'CELL' named entity 'BUT' named entity 'BORNE' named entity 'THESE' named entity 'CLEARANCE' named entity 'DIVERSITY'

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